Department of Dermatology and Venereology, All India Institute of Medical Sciences New Delhi-110 029, India.
Indian J Dermatol Venereol Leprol. 2010 Jan-Feb;76(1):56-8. doi: 10.4103/0378-6323.58681.
Lichen sclerosus (LS) is a chronic inflammatory skin disease, which most commonly involves the anogenital region. The etiology of LS is obscure, but genetic susceptibility, autoimmune mechanisms, infective agents like human papillomavirus and spirochaetes, and Koebner phenomenon has been postulated as causative factors. We report our observation in 6 patients (3 males and 3 females) with histologically proven lichen sclerosus that showed relative sparing of the uncovered areas of the genitals, thereby suggesting that the occlusion of the genital skin may be playing a greater role in the causation of LS than is currently thought, in both sexes.
硬化性苔藓（LS）是一种慢性炎症性皮肤病，最常累及肛门生殖器区域。LS 的病因尚不清楚，但遗传易感性、自身免疫机制、人乳头瘤病毒和螺旋体等感染因子以及 Koebner 现象已被推测为致病因素。我们报告了 6 例（3 男 3 女）组织学证实的硬化性苔藓患者的观察结果，这些患者的生殖器未覆盖区域相对保留，这表明生殖器皮肤的闭塞可能在两性 LS 的发病中比目前认为的更为重要。
