Guy's and St Thomas' Hospital, St John's Institute of Dermatology, London, UK.
Br J Dermatol. 2013 Mar;168(3):643-6. doi: 10.1111/bjd.12014.
Lichen sclerosus (LS) is a chronic inflammatory skin disorder that typically affects the anogenital area. It presents with ivory-white atrophic patches or plaques with associated telangiectasia and occasional purpura. It has rarely been described as affecting abdominal stomas.
To investigate possible aetiological factors responsible for the development of this condition.
All patients with peristomal LS were identified at a specialist stoma dermatology clinic and studied using a standardized pro forma.
We identified 12 patients with peristomal LS. The mean age was 72·3 years (range 47-85 years). With the exception of one patient, all our other patients had urostomies. Treatment was effective in the majority of cases.
Peristomal LS, in our experience, is most commonly found around urostomies, and we speculate that in addition to the possible role of local trauma and occlusion, certain - as yet unidentified - constituents in the urine possibly play a role in its aetiology. It tends to respond well to corticosteroids and has not been associated with malignant transformation.
硬化性苔藓（LS）是一种慢性炎症性皮肤病，通常影响肛门生殖器区域。其表现为象牙白色萎缩斑块或斑块，伴有毛细血管扩张和偶尔出现紫癜。它很少被描述为影响腹部造口。
调查可能导致这种情况发生的病因因素。
在专门的造口皮肤病诊所，我们通过标准化的表格确定了所有患有肛周 LS 的患者，并对其进行了研究。
我们确定了 12 例肛周 LS 患者。平均年龄为 72.3 岁（范围 47-85 岁）。除了一名患者外，我们所有其他患者都有尿流改道术。大多数情况下，治疗是有效的。
根据我们的经验，肛周 LS 最常见于尿流改道术周围，我们推测，除了局部创伤和闭塞的可能作用外，尿液中的某些（尚未确定的）成分可能在其发病机制中起作用。它对皮质类固醇反应良好，且尚未与恶性转化相关。
