Data Mining Department, Institute for Infocomm Research, 1 Fusionopolis Way, 21-01 Connexis South Tower, Singapore 138632, Singapore.
Drug Discov Today. 2011 Jan;16(1-2):42-9. doi: 10.1016/j.drudis.2010.10.007. Epub 2010 Oct 23.
Knowledge of infectious diseases now emerging from genomic, proteomic, epidemiological and clinical data can provide insights into the mechanisms of immune function, disease pathogenesis and epidemiology. Here, we describe how considerable advances in computational methods of data mining, mathematical modeling in epidemiology and simulation have been used to enhance our understanding of infectious agents and discuss their impact on the discovery of new therapeutics and controlling their spread.
从基因组学、蛋白质组学、流行病学和临床数据中涌现出的传染病知识，可以深入了解免疫功能、疾病发病机制和流行病学的机制。在这里，我们描述了数据挖掘的计算方法、流行病学中的数学建模和模拟方面的重大进展如何被用来提高我们对传染病的认识，并讨论它们对发现新疗法和控制其传播的影响。
