Department of Nutritional Sciences, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada.
J Midwifery Womens Health. 2010 Nov-Dec;55(6):550-60. doi: 10.1016/j.jmwh.2010.02.016.
Vitamin D deficiency is a highly prevalent condition that is present in 40% to 80% of pregnant women. There is emerging evidence that vitamin D deficiency may be a risk modifying factor for many chronic diseases, including osteomalacia, rickets, multiple sclerosis, schizophrenia, heart disease, type 1 diabetes, and cancer. Heightened susceptibility to these diseases may originate in early life during the development of tissue structure and function. It is suspected that biologic mechanisms can "memorize" the metabolic effects of early nutritional environment through fetal and neonatal imprinting. Inadequate vitamin D nutrition during perinatal life may establish a poor foundation that may produce long-term threats to human health. This review summarizes the risks of vitamin D deficiency for human health and provides the current vitamin D recommendations for mothers and their newborns.
维生素 D 缺乏是一种非常普遍的情况，40%至 80%的孕妇都存在这种情况。有新的证据表明，维生素 D 缺乏可能是许多慢性疾病的风险修饰因素，包括骨软化症、佝偻病、多发性硬化症、精神分裂症、心脏病、1 型糖尿病和癌症。这些疾病的易感性增加可能起源于生命早期组织结构和功能的发育过程中。人们怀疑生物机制可以通过胎儿和新生儿印记“记住”早期营养环境的代谢影响。围产期维生素 D 营养不足可能会为人类健康奠定不良基础，从而对人类健康造成长期威胁。本综述总结了维生素 D 缺乏对人类健康的风险，并提供了目前母亲及其新生儿的维生素 D 推荐量。
