Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Nat Commun. 2010 Apr 12;1:6. doi: 10.1038/ncomms1004.
Proteins and nucleic acids are sequence-regulated macromolecules with various properties originating from their perfectly sequenced primary structures. However, the sequence regulation of synthetic polymers, particularly vinyl polymers, has not been achieved and is one of the ultimate goals in polymer chemistry. In this study, we report a strategy to obtain sequence-regulated vinyl copolymers consisting of styrene, acrylate and vinyl chloride units using metal-catalysed step-growth radical polyaddition of designed monomers prepared from common vinyl monomer building blocks. Unprecedented ABCC-sequence-regulated copolymers with perfect vinyl chloride-styrene-acrylate-acrylate sequences were obtained by copper-catalysed step-growth radical polymerization of designed monomers possessing unconjugated C=C and reactive C-Cl bonds. This strategy may open a new route in the study of sequence-regulated synthetic polymers.
蛋白质和核酸是序列调节的大分子，具有各种特性，这些特性源于其完全有序的一级结构。然而，合成聚合物，特别是乙烯基聚合物的序列调节尚未实现，这是聚合物化学的最终目标之一。在这项研究中，我们报告了一种使用金属催化的设计单体逐步增长自由基加成聚合来获得由苯乙烯、丙烯酸酯和氯乙烯单元组成的序列调节的乙烯基共聚物的策略，这些设计单体由常见的乙烯基单体构建块制备。通过铜催化具有非共轭 C=C 和反应性 C-Cl 键的设计单体的逐步增长自由基聚合，获得了具有完美的氯乙烯-苯乙烯-丙烯酸酯-丙烯酸酯序列的 ABCC 序列调节共聚物。这种策略可能为序列调节合成聚合物的研究开辟新途径。
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