Institute of Polymers Chemistry and Technology, CNR, Via Campi Flegrei 34, 80078 Pozzuoli, Naples, Italy.
J Mater Sci Mater Med. 2010 Nov;21(11):2923-36. doi: 10.1007/s10856-010-4156-8. Epub 2010 Oct 7.
In the present article, several developments of biocomposites containing silica nanoparticles intended for bone regeneration are reported. Nanocomposites of poly(ε-caprolactone) (PCL) and silica, in which either the silica nanoparticles or the PCL have been modified in order to improve interfacial adhesion through chemical graft between the phases are hereafter described. The composites are characterized with respect to their chemical-physical and mechanical properties. Their biocompatibility and capacity to induce the osteoblastic phenotype in human bone marrow mesenchymal stem cells have been assessed.
本文报道了几种用于骨再生的含二氧化硅纳米粒子的生物复合材料的进展。聚己内酯（PCL）和二氧化硅的纳米复合材料，其中通过相之间的化学接枝来改善界面粘附，要么对二氧化硅纳米粒子进行改性，要么对 PCL 进行改性。此后对复合材料的化学物理和机械性能进行了描述。评估了它们的生物相容性和在人骨髓间充质干细胞中诱导成骨表型的能力。
