利用 Petasis 反应和 1,3-偶极环加成反应拓展立体化学和骨架多样性。
Expanding stereochemical and skeletal diversity using petasis reactions and 1,3-dipolar cycloadditions.
机构信息
Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138, United States.
出版信息
Org Lett. 2010 Nov 19;12(22):5230-3. doi: 10.1021/ol102266j. Epub 2010 Oct 26.
Abstract
A short and modular synthetic pathway using intramolecular 1,3-dipolar cycloaddition reactions and yielding functionalized isoxazoles, isoxazolines, and isoxazolidines is described. The change in shape of previous compounds and those in this study is quantified and compared using principal moment-of-inertia shape analysis.
摘要
描述了一种使用分子内 1,3-偶极环加成反应的短而模块化的合成途径，可生成功能化的异恶唑、异恶唑啉和异恶唑烷。使用主惯性矩形状分析定量和比较了以前化合物和本研究中化合物的形状变化。
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