Wang Xiaolin, Zhang Min, Li Jianjian, Li Tianyi, Sun Changrong, Li Hanping, Liu Yongjian, Liu Siyang, Zhuang Daomin, Bao Zuoyi, Han Jingwan, Li Jingyun, Li Lin
1 State Key Laboratory of Pathogen and Biosecurity, Department of AIDS Research, Beijing Institute of Microbiology and Epidemiology , Beijing, China .
2 Anhui Medical University , Anhui, China .
AIDS Res Hum Retroviruses. 2017 Jun;33(6):614-620. doi: 10.1089/AID.2017.0013.
Since the first identification of HIV-1 outbreak in Dehong, Yunnan province has been the epidemic center of HIV in China. Owing to the special geographic location and the frequent population mobility, Yunnan province contained complex HIV subtype distribution. Many new circulating recombinant forms (CRFs) and unique recombinant forms (URFs) have been found in recent years. In this study, a unique HIV-1 recombinant strain genome (YN10134) was characterized from an HIV-positive female in Yunnan, China. This virus genome had a complex intersubtype recombinant structure with eight breakpoints, composed of subtypes B and C. Although the sequence had a similar breakpoint with CRF07_BC in the start position in Env, the phylogenetic analysis showed that the segment was not originated from CRF07_BC. The identification of the URF indicated the severity of the HIV epidemic in Yunnan province and the urgent need for epidemiological surveillance of the new recombination.
自首次在云南省德宏州发现HIV-1疫情以来，该省一直是中国HIV的流行中心。由于特殊的地理位置和频繁的人口流动，云南省HIV亚型分布复杂。近年来发现了许多新的循环重组型（CRF）和独特重组型（URF）。在本研究中，从中国云南省一名HIV阳性女性中鉴定出一种独特的HIV-1重组毒株基因组（YN10134）。该病毒基因组具有复杂的亚型间重组结构，有8个断点，由B和C亚型组成。虽然该序列在Env起始位置与CRF07_BC有相似的断点，但系统发育分析表明该片段并非源自CRF07_BC。该URF的鉴定表明云南省HIV疫情的严重性以及对新重组体进行流行病学监测的迫切需求。
