La Roche-Posay Pharmaceutical Laboratories, 110 Avenue Henri Barbusse, 92602 Asnières Cedex, France.
Br J Dermatol. 2010 Nov;163(5):903-14. doi: 10.1111/j.1365-2133.2010.10018.x.
The effects of acute or repeated suberythemal solar ultraviolet radiation (UVR) exposure on human skin have been insufficiently investigated. Such exposure almost certainly has important long-term consequences that include skin ageing and skin cancer. This review summarizes the published data on the biological effects of suberythemal exposure using a wide range of clinical, cellular and molecular endpoints, some of which may be considered as biomarkers for skin cancer and photoageing. We also include some recent unpublished results from our laboratories. The effects of UVA (320-400 nm), UVB (290-320 nm) and total solar UVR (290-400 nm) are compared. We demonstrate that avoiding sunburn does not prevent many indicators of cutaneous biological damage and that use of low sun protection factor (SPF) sunscreen can inhibit much of the damages induced by suberythemal exposure to UVR. However, even when applied correctly, sunscreen use will result in suberythemal exposure. The degree and spectral quality of such exposure will depend on the SPF and absorption spectrum of the sunscreen, but nonetheless it may contribute to cumulative photodamage. This review may help to determine the level of photoprotection required in sunscreens and daily use products, as well as the ideal ratio of UVB/UVA protection, to improve long-term photoprotection outcomes.
急性或反复亚红斑量太阳紫外线（UVR）暴露对人类皮肤的影响尚未得到充分研究。这种暴露几乎肯定会产生重要的长期后果，包括皮肤老化和皮肤癌。本综述总结了使用广泛的临床、细胞和分子终点研究亚红斑量暴露的生物学效应的已发表数据，其中一些终点可被视为皮肤癌和光老化的生物标志物。我们还包括了来自我们实验室的一些最近未发表的结果。比较了 UVA（320-400nm）、UVB（290-320nm）和总太阳 UVR（290-400nm）的影响。我们证明，避免晒伤并不能预防许多皮肤生物学损伤的指标，并且使用低防晒因子（SPF）防晒霜可以抑制亚红斑量 UVR 暴露引起的许多损伤。然而，即使正确使用，防晒霜的使用也会导致亚红斑量暴露。这种暴露的程度和光谱质量将取决于防晒霜的 SPF 和吸收光谱，但它仍可能导致累积光损伤。本综述可能有助于确定防晒霜和日常使用产品所需的光保护水平，以及改善长期光保护效果的理想 UVB/UVA 保护比。
