Department of Infectious Diseases, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
J Infect Dis. 2010 Dec 1;202(11):1634-8. doi: 10.1086/657084. Epub 2010 Oct 27.
Levels of preexisting antibodies to the hemagglutinin of pandemic influenza A(H1N1) 2009 (hereafter pandemic H1N1) virus positively correlate with age. The impact of contemporary seasonal influenza vaccines on establishing immunity to other pandemic H1N1 proteins is unknown. We measured serum antibodies to the neuraminidase (NA) of pandemic H1N1 in adults prior to and after vaccination with seasonal trivalent inactivated influenza vaccines. Serum antibodies to pandemic H1N1 NA were observed in all age groups; however, vaccination elevated levels of pandemic H1N1 NA antibodies predominately in elderly individuals (age, ⩾60 years). Therefore, contemporary seasonal vaccines likely contribute to reduction of pandemic H1N1-associated disease in older individuals.
先前存在的针对大流行流感 A(H1N1) 病毒血凝素的抗体水平与年龄呈正相关。(这里简称大流行 H1N1)目前尚不清楚当代季节性流感疫苗对建立针对其他大流行 H1N1 蛋白的免疫力的影响。我们在接种季节性三价灭活流感疫苗之前和之后测量了成年人血清中针对大流行 H1N1 的神经氨酸酶(NA)的抗体。所有年龄组均观察到针对大流行 H1N1 NA 的血清抗体;然而,疫苗主要在老年人(年龄 ⩾60 岁)中提高了大流行 H1N1 NA 抗体水平。因此,当代季节性疫苗可能有助于减少老年人中与大流行 H1N1 相关的疾病。