米索硝唑给药的最佳方案及多中心临床试验的开展
The optimum regime for the administration of misonidazole and the establishment of multi-centre clinical trials.
作者信息
Dische S, Saunders M I, Flockhart I R
出版信息
Br J Cancer Suppl. 1978 Jun;3:318-21.
Abstract
The amount of misonidazole which may be given to one patient is limited because of the risk of neurotoxicity. The drug may be given with every treatment of a multi-fraction course of radiotherapy or only with some of the treatments. The number of radiotherapy treatments can be reduced or multiple treatments given after each dose of the drug. Experience in 19 patients given daily doses of misonidazole is reported. This is practical regime to be considered for clinical trials of this hypoxic cell sensitizer.
摘要
由于存在神经毒性风险，给予单个患者的米索硝唑剂量是有限的。该药物可在多疗程放射治疗的每次治疗时给予，或仅在部分治疗时给予。放射治疗的次数可以减少，或者在每次给药后进行多次治疗。报告了19例每日给予米索硝唑患者的经验。这是在对这种乏氧细胞增敏剂进行临床试验时可考虑的实用方案。
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引用本文的文献
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Low concentrations of misonidazole counteract effects of extreme hypoxia on cells in S.低浓度的米索硝唑可抵消极端缺氧对S期细胞的影响。
Br J Cancer. 1981 Mar;43(3):355-66. doi: 10.1038/bjc.1981.56.
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Cell-cycle inhibition by misonidazole of human cells cultivated in vitro under aerobic conditions.在有氧条件下体外培养的人细胞中，米索硝唑对细胞周期的抑制作用。
Br J Cancer. 1979 Nov;40(5):755-60. doi: 10.1038/bjc.1979.257.
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Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
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