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米索硝唑的临床经验。

Clinical experience with misonidazole.

作者信息

Dische S, Saunders M I

出版信息

Br J Cancer Suppl. 1978 Jun;3:311-3.

PMID:277252
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149429/
Abstract

A total of 62 patients with advanced tumours have now been treated by a fractionated course of radiotherapy, with misonidazole. The prime purpose of the administration of the drug to these patients was to determine safe dosage and suitable regimes for use in clinical radiotherapy. The reaction of normal tissues did not seem enhanced but there was an impression of increased tumour response.

摘要

共有62例晚期肿瘤患者接受了使用米索硝唑的分次放射治疗疗程。给这些患者使用该药物的主要目的是确定临床放射治疗中安全的剂量和合适的治疗方案。正常组织的反应似乎没有增强,但有肿瘤反应增加的迹象。

相似文献

1
Clinical experience with misonidazole.米索硝唑的临床经验。
Br J Cancer Suppl. 1978 Jun;3:311-3.
2
The optimum regime for the administration of misonidazole and the establishment of multi-centre clinical trials.米索硝唑给药的最佳方案及多中心临床试验的开展
Br J Cancer Suppl. 1978 Jun;3:318-21.
3
Prolonged metronidazole administration with protracted radiotherapy: a pilot study on response of advanced tumours.长期使用甲硝唑并延长放疗时间:一项关于晚期肿瘤反应的初步研究。
Br J Cancer Suppl. 1978 Jun;3:299-301.
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Radiosensitization by misonidazole (Ro-07-0582) of fractionated X-rays in a murine tumour.米索硝唑(Ro-07-0582)对小鼠肿瘤分次X射线的放射增敏作用。
Br J Cancer Suppl. 1978 Jun;3:242-5.
5
[Clinical experiences with the radiation-sensitizing agent misonidazole].[放射增敏剂米索硝唑的临床经验]
Strahlentherapie Sonderb. 1978;75:115-9.
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The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.米索硝唑的神经毒性及其与剂量、半衰期和血清浓度的关系。
Br J Cancer Suppl. 1978 Jun;3:268-70.
7
Clinical experience with misonidazole: high dose fractions versus daily low doses.米索硝唑的临床经验:高剂量分次给药与每日低剂量给药对比
Cancer Clin Trials. 1980 Summer;3(2):179-86.
8
[Clinical studies of combined therapy of radiation and local injection of misonidazole].放射治疗与局部注射米索硝唑联合治疗的临床研究
Nihon Igaku Hoshasen Gakkai Zasshi. 1983 May 25;43(5):675-84.
9
[Clinical evaluation of hypoxic cell sensitizer (Misonidazole)].[乏氧细胞增敏剂(米索硝唑)的临床评价]
Gan To Kagaku Ryoho. 1984 Jun;11(6):1225-30.
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Misonidazole in fractionated radiotherapy: are many small fractions best?米索硝唑在分次放射治疗中的应用:多次小剂量分割是否最佳?
Br J Radiol. 1980 Oct;53(634):981-90. doi: 10.1259/0007-1285-53-634-981.

引用本文的文献

1
The search for new hypoxic cell radiosensitizers.新型低氧细胞放射增敏剂的研究
J Natl Med Assoc. 1980 Aug;72(8):765-9.
2
Cytotoxicity of metronidazole (Flagyl) and misonidazole (Ro-07-0582): enhancement by lactate.甲硝唑(灭滴灵)和米索硝唑(Ro-07-0582)的细胞毒性:乳酸的增强作用
Br J Cancer. 1981 Mar;43(3):350-4. doi: 10.1038/bjc.1981.55.

本文引用的文献

1
The hyperbaric oxygen chamber in the radiotherapy of carcinoma of the uterine cervix.
Br J Radiol. 1974 Feb;47(554):99-107. doi: 10.1259/0007-1285-47-554-99.
2
Clinical testing of the radiosensitiser Ro-07-0582. II. Radiosensitisation of normal and hypoxic skin.放射增敏剂Ro-07-0582的临床试验。II. 正常皮肤和缺氧皮肤的放射增敏作用
Clin Radiol. 1976 Apr;27(2):159-66. doi: 10.1016/s0009-9260(76)80138-9.
3
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验:多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
4
Clinical testing of the radiosensitiser Ro-07-0582. III. Response of tumours.放射增敏剂Ro-07-0582的临床试验。III. 肿瘤反应
Clin Radiol. 1976 Apr;27(2):167-74. doi: 10.1016/s0009-9260(76)80139-0.
5
Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations.放射增敏剂Ro-07-0582的临床试验。I. 剂量耐受性、血清和肿瘤浓度。
Clin Radiol. 1976 Apr;27(2):151-7. doi: 10.1016/s0009-9260(76)80137-7.