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1
The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.米索硝唑的神经毒性及其与剂量、半衰期和血清浓度的关系。
Br J Cancer Suppl. 1978 Jun;3:268-70.
2
The optimum regime for the administration of misonidazole and the establishment of multi-centre clinical trials.米索硝唑给药的最佳方案及多中心临床试验的开展
Br J Cancer Suppl. 1978 Jun;3:318-21.
3
Peripheral neuropathy related to misonidazole: incidence and pathology.与米索硝唑相关的周围神经病变：发病率与病理学
Br J Cancer Suppl. 1978 Jun;3:271-5.
4
Further clinical experiences of a phase I study with the hypoxic cell radiosensitizer misonidazole.乏氧细胞放射增敏剂米索硝唑I期研究的进一步临床经验
Br J Cancer Suppl. 1978 Jun;3:281-5.
5
Misonidazole peripheral neuropathy: its relationship to plasma concentration and other drugs.米索硝唑周围神经病变：其与血药浓度及其他药物的关系。
Cancer Clin Trials. 1980 Summer;3(2):105-9.
6
Dose-response curves for predicting misonidazole-induced peripheral neuropathy.预测米索硝唑诱导的周围神经病变的剂量反应曲线。
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7
Relationship between the neurotoxicity of the hypoxic cell radiosensitizer SR 2508 and the pharmacokinetic profile.
Cancer Res. 1987 Jan 1;47(1):319-22.
8
Plasma concentration of misonidazole and peripheral neuropathy.米索硝唑的血浆浓度与周围神经病变
Am J Clin Oncol. 1982 Apr;5(2):239-40.
9
Clinical experience with misonidazole: high dose fractions versus daily low doses.米索硝唑的临床经验：高剂量分次给药与每日低剂量给药对比
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Misonidazole in the preoperative and radical radiotherapy of bladder cancer.米索硝唑在膀胱癌术前及根治性放疗中的应用
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The Therapeutic Potential of Imidazole or Quinone-Based Compounds as Radiosensitisers in Combination with Radiotherapy for the Treatment of Head and Neck Squamous Cell Carcinoma.咪唑或醌类化合物作为放射增敏剂与放射疗法联合治疗头颈部鳞状细胞癌的治疗潜力
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Evaluation of Optimal Post-Injection Timing of Hypoxic Imaging with F-Fluoromisonidazole-PET/CT.评估 F-氟咪索硝唑-PET/CT 缺氧成像的最佳注射后时间。
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Molecular imaging of hypoxia in non-small-cell lung cancer.非小细胞肺癌中缺氧的分子成像
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Clinical results of hypoxic cell radiosensitisation from hyperbaric oxygen to accelerated radiotherapy, carbogen and nicotinamide.从高压氧到加速放疗、卡波金和烟酰胺的乏氧细胞放射增敏的临床结果。
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A biochemical method for assessing the neurotoxic effects of misonidazole in the rat.一种评估米索硝唑对大鼠神经毒性作用的生化方法。
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Effect of acute and chronic misonidazole administration on peripheral-nerve electrophysiology in mice.急性和慢性给予米索硝唑对小鼠周围神经电生理学的影响。
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Phenytoin shortens the half-life of the hypoxic cell radiosensitizer misonidazole in man: implications for possible reduced toxicity.苯妥英钠可缩短人体中缺氧细胞放射增敏剂米索硝唑的半衰期：对可能降低毒性的意义。
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9
Pharmacokinetic and tumour-penetration properties of the hypoxic cell radiosensitizer desmethylmisonidazole (Ro 05-Ro-9963) in dogs.乏氧细胞放射增敏剂去甲基米索硝唑（Ro 05-Ro-9963）在犬体内的药代动力学及肿瘤穿透特性
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10
Quantitative cytochemical assessment of the neurotoxicity of misonidazole in the mouse.米索硝唑对小鼠神经毒性的定量细胞化学评估
Br J Cancer. 1982 Apr;45(4):582-7. doi: 10.1038/bjc.1982.95.

本文引用的文献

1
Serum concentration measurements in man of the radiosensitizer Ro-07-0582: some preliminary results.放射增敏剂Ro-07-0582在人体中的血清浓度测量：一些初步结果。
Br J Cancer. 1975 Jun;31(6):679-83. doi: 10.1038/bjc.1975.115.
2
Clinical testing of the radiosensitizer Ro 07-0582: experience with multiple doses.放射增敏剂Ro 07-0582的临床试验：多次给药的经验
Br J Cancer. 1977 May;35(5):567-79. doi: 10.1038/bjc.1977.90.
3
Clinical testing of the radiosensitiser Ro-07-0582. I. Dose tolerance, serum and tumour concentrations.放射增敏剂Ro-07-0582的临床试验。I. 剂量耐受性、血清和肿瘤浓度。
Clin Radiol. 1976 Apr;27(2):151-7. doi: 10.1016/s0009-9260(76)80137-7.

米索硝唑的神经毒性及其与剂量、半衰期和血清浓度的关系。

The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.

作者信息

Saunders M E, Dische S, Anderson P, Flockhart I R

出版信息

Br J Cancer Suppl. 1978 Jun;3:268-70.

PMID:209808
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2149393/
Abstract

Misonidazole has been given to a total of 87 patients. Neurotoxicity has occurred--convulsions with the higher doses and peripheral neuropathy with the lowern ones. The data from 34 patients receiving 4--7 doses has been analysed. Peripheral neuropathy is related to the total tissue exposure. By monitoring serum levels and controlling the total dose given, convulsions are avoidable and peripheral neuropathy restricted to a low and acceptable level.

摘要

共有87名患者接受了米索硝唑治疗。出现了神经毒性——高剂量时出现惊厥，低剂量时出现周围神经病变。对34名接受4至7次剂量治疗的患者的数据进行了分析。周围神经病变与总的组织暴露量有关。通过监测血清水平并控制给药总量，可以避免惊厥的发生，并将周围神经病变限制在较低的可接受水平。