米索硝唑的神经毒性及其与剂量、半衰期和血清浓度的关系。
The neurotoxicity of misonidazole and its relationship to dose, half-life and concentration in the serum.
作者信息
Saunders M E, Dische S, Anderson P, Flockhart I R
出版信息
Br J Cancer Suppl. 1978 Jun;3:268-70.
Abstract
Misonidazole has been given to a total of 87 patients. Neurotoxicity has occurred--convulsions with the higher doses and peripheral neuropathy with the lowern ones. The data from 34 patients receiving 4--7 doses has been analysed. Peripheral neuropathy is related to the total tissue exposure. By monitoring serum levels and controlling the total dose given, convulsions are avoidable and peripheral neuropathy restricted to a low and acceptable level.
摘要
共有87名患者接受了米索硝唑治疗。出现了神经毒性——高剂量时出现惊厥，低剂量时出现周围神经病变。对34名接受4至7次剂量治疗的患者的数据进行了分析。周围神经病变与总的组织暴露量有关。通过监测血清水平并控制给药总量，可以避免惊厥的发生，并将周围神经病变限制在较低的可接受水平。
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