Anderson H A, Wolff M S, Fischbein A, Selikoff I J
Environ Health Perspect. 1978 Apr;23:187-91. doi: 10.1289/ehp.7823187.
Clinical findings are reported for a group of 55 employees of the Michigan Chemical Corporation which manufactured FireMaster BP-6 from 1970 to 1974, in addition to a variety of other halogenated fire retardant chemicals. The results are compared with those from a group of male farm residents and consumers from Michigan examined at the same time. An increased prevalence of chest and skin symptoms was observed, compared with farmers. Skin symptoms were more prevalent among former PBB production personnel. Musculosketal symptoms were less prevalent among these workers than among farmers. Serum PBB concentrations are signicantly higher than among farmers. Blood chemistry results were similar for workers and farmers. However, both groups exhibited a significantly higher prevalence of elevated liver function tests (SGOT, SPGT) than a control population of nonexposed farmers. Both farmers and chemical workers showed an association of elevated CEA with serum PBB greater than 10 ppb.
报告了密歇根化学公司55名员工的临床检查结果,该公司在1970年至1974年期间生产FireMaster BP - 6,此外还生产各种其他卤化阻燃化学品。将结果与同一时期接受检查的一组密歇根男性农场居民和消费者的结果进行了比较。与农民相比,观察到胸部和皮肤症状的患病率有所增加。皮肤症状在前多溴联苯生产人员中更为普遍。这些工人的肌肉骨骼症状比农民中更为少见。血清多溴联苯浓度显著高于农民。工人和农民的血液化学结果相似。然而,两组肝功能测试(SGOT、SPGT)升高的患病率均显著高于未接触化学物质的农民对照组。农民和化学工人均显示癌胚抗原升高与血清多溴联苯大于10 ppb有关。