Kerenyi N A, Pandula E, Feuer G M
Department of Pathology, Sunnybrook Medical Centre, University of Toronto, Canada.
Drug Metabol Drug Interact. 1990;8(3-4):313-9.
There is increasing evidence that the pineal gland has a role in the control of neoplastic processes. Kerenyi found hyperplasia of the pineal gland in patients with widely disseminated malignant melanoma. Feuer and Kerenyi reported significantly higher serum melatonin levels with malignant melanoma. Beral et al. found 2.1 times increased risks of melanoma and Pasternak et al. described a relative risk of 1.87, related to exposure to fluorescent light. In our study, white New Zealand rabbits were exposed for 12 months to fluorescent light. The serum melatonin levels of the control group were significantly higher, p less than 0.005. According to Cohen, the pineal gland has a role in the etiology of breast cancer. Melatonin inhibits MCF-7 human breast cancer cell growth in culture. In our study of 500 surgically removed breast tumors, 254 were melatonin receptor positive, 246 negative. Most melatonin receptor positive breast cancer occurred between 60-65 years of age, receptor negative breast cancer peaked between 40-45 years. Benign breast tumors were almost invariably melatonin receptor positive. It is proposed that melatonin may have a direct effect on breast tumors, the melatonin receptors being the probable sites of interaction between melatonin and the tumor cell.
越来越多的证据表明，松果体在肿瘤形成过程的控制中发挥作用。凯伦伊发现广泛播散性恶性黑色素瘤患者的松果体增生。费尔和凯伦伊报告恶性黑色素瘤患者血清褪黑素水平显著升高。贝拉尔等人发现患黑色素瘤的风险增加了2.1倍，帕斯特纳克等人描述与接触荧光灯相关的相对风险为1.87。在我们的研究中，将白色新西兰兔暴露于荧光灯下12个月。对照组的血清褪黑素水平显著更高，p值小于0.005。根据科恩的研究，松果体在乳腺癌的病因学中起作用。褪黑素在培养中抑制MCF-7人乳腺癌细胞生长。在我们对500例手术切除的乳腺肿瘤的研究中，254例褪黑素受体呈阳性，246例呈阴性。大多数褪黑素受体阳性乳腺癌发生在60至65岁之间，受体阴性乳腺癌在40至45岁之间达到峰值。良性乳腺肿瘤几乎总是褪黑素受体阳性。有人提出褪黑素可能对乳腺肿瘤有直接作用，褪黑素受体可能是褪黑素与肿瘤细胞相互作用的部位。
