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转化生长因子-β:问题与前景

TGF-beta: problems and prospects.

作者信息

Sporn M B, Roberts A B

机构信息

Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892.

出版信息

Cell Regul. 1990 Nov;1(12):875-82. doi: 10.1091/mbc.1.12.875.

DOI:10.1091/mbc.1.12.875
PMID:2100192
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC362858/
Abstract

TGF-beta research is proceeding at an exponential pace. Studies in this area have become increasingly relevant to many areas of cell regulation, continually providing new surprises and findings. One may confidently predict that TGF-beta will be one of the key molecules in future attempts to establish an integrated view of the processes whereby cells coordinate their own and mutual functions. We have seen only the beginning, and this minireview is only a glimpse.

摘要

转化生长因子-β(TGF-β)的研究正以指数级速度推进。该领域的研究与细胞调控的许多领域越来越相关,不断带来新的惊喜和发现。人们可以有信心地预测,TGF-β将成为未来尝试建立细胞协调自身及相互功能过程的综合观点时的关键分子之一。我们所见的仅仅是开始,而这篇小型综述也只是略窥一斑。

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TGF-beta: problems and prospects.转化生长因子-β:问题与前景
Cell Regul. 1990 Nov;1(12):875-82. doi: 10.1091/mbc.1.12.875.
2
Meeting report: signaling schemes for TGF-beta.会议报告:转化生长因子-β的信号传导机制
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How cells read TGF-beta signals.细胞如何解读转化生长因子-β信号。
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本文引用的文献

1
Purification and properties of a type beta transforming growth factor from bovine kidney.牛肾β型转化生长因子的纯化及性质
Biochemistry. 1983 Dec 6;22(25):5692-8. doi: 10.1021/bi00294a002.
2
Purification and initial characterization of a type beta transforming growth factor from human placenta.从人胎盘中纯化并初步鉴定一种β型转化生长因子。
Proc Natl Acad Sci U S A. 1983 Jun;80(12):3676-80. doi: 10.1073/pnas.80.12.3676.
3
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization.人类血小板中的转化生长因子-β。主要储存部位的鉴定、纯化及特性分析。
J Biol Chem. 1983 Jun 10;258(11):7155-60.
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Type beta transforming growth factor: a bifunctional regulator of cellular growth.β型转化生长因子:细胞生长的双功能调节因子。
Proc Natl Acad Sci U S A. 1985 Jan;82(1):119-23. doi: 10.1073/pnas.82.1.119.
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Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells.人转化生长因子-β互补DNA序列及其在正常细胞和转化细胞中的表达。
Nature. 1985;316(6030):701-5. doi: 10.1038/316701a0.
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Purification and characterization of two cartilage-inducing factors from bovine demineralized bone.从牛脱矿骨中纯化及鉴定两种软骨诱导因子
Proc Natl Acad Sci U S A. 1985 Apr;82(8):2267-71. doi: 10.1073/pnas.82.8.2267.
7
Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.软骨诱导因子-A。与转化生长因子-β明显相同。
J Biol Chem. 1986 May 5;261(13):5693-5.
8
T cell suppressor factor from human glioblastoma cells is a 12.5-kd protein closely related to transforming growth factor-beta.来自人胶质母细胞瘤细胞的T细胞抑制因子是一种与转化生长因子-β密切相关的12.5千道尔顿蛋白质。
EMBO J. 1987 Jun;6(6):1633-6. doi: 10.1002/j.1460-2075.1987.tb02411.x.
9
Type 1 transforming growth factor beta: amplified expression and secretion of mature and precursor polypeptides in Chinese hamster ovary cells.1型转化生长因子β:中国仓鼠卵巢细胞中成熟和前体多肽的表达及分泌增强
Mol Cell Biol. 1987 Oct;7(10):3418-27. doi: 10.1128/mcb.7.10.3418-3427.1987.
10
Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.软骨诱导因子-B是一种在结构和功能上与转化生长因子-β相关的独特蛋白质。
J Biol Chem. 1987 Feb 15;262(5):1946-9.