Luetzeler J, Heine U
Intervirology. 1978;10(5):289-99. doi: 10.1159/000148991.
New ultrastructural findings within the nucleus of herpes simplex virus-infected cells are illustrated. The occurrence of bundles of tightly packed filaments during the late stages of the infectious process is described. These bundles were found in different areas of the nucleus and were not associated with any nuclear organelles. Employing different staining techniques and high-resolution autoradiography, they could be identified as DNA-containing nucleoproteins. These filaments may be interpreted as a special form of viral DNA accumulation within the nucleus. Changes of these structures toward a more recticular arrangement were observed as soon as the nucleoplasm disintegrated.
本文展示了单纯疱疹病毒感染细胞细胞核内新的超微结构发现。描述了在感染过程后期紧密排列的细丝束的出现。这些细丝束存在于细胞核的不同区域，且与任何核细胞器均无关联。采用不同的染色技术和高分辨率放射自显影术，可将它们鉴定为含DNA的核蛋白。这些细丝可被解释为病毒DNA在细胞核内积累的一种特殊形式。一旦核质解体，就观察到这些结构向更呈网状排列的变化。
