Unit of Skin Oncology, University Hospital Center, Nantes, France.
J Eur Acad Dermatol Venereol. 2011 Jun;25(6):695-704. doi: 10.1111/j.1468-3083.2010.03852.x. Epub 2010 Oct 3.
Superficial chemical peels offer therapeutic results in a convenient, affordable treatment. Many clinicians use these peels in the treatment of acne and acne-prone oily skin.
This article examines the evidence base that supports the widespread use of superficial peels in this setting.
A search of the English language medical literature was performed to identify clinical trials that formally evaluated the use of chemical peeling in active acne.
Search of the literature revealed very few clinical trials of peels in acne (N=13); a majority of these trials included small numbers of patients, were not controlled and were open label. The evidence that is available does support the use of chemical peels in acne as all trials had generally favourable results despite differences in assessments, treatment regimens and patient populations. Notably, no studies of chemical peels have used an acne medication as a comparator. As not every publication specified whether or not concomitant acne medications were allowed, it is hard to evaluate clearly how many of the studies evaluated the effect of peeling alone. This may be appropriate, however, given that few clinicians would use superficial chemical peels as the sole treatment for acne except in rare instances where a patient could not tolerate other treatment modalities.
In the future, further study is needed to determine the best use of chemical peels in this indication.
浅层化学焕肤以其便捷、经济的治疗优势，为患者带来了显著的疗效。许多临床医生将其应用于痤疮和痤疮油性皮肤的治疗中。
本文旨在探讨浅层化学焕肤在该治疗领域的广泛应用的循证医学依据。
我们对英文医学文献进行了检索，以确定正式评估化学焕肤在活动性痤疮中应用的临床试验。
文献检索结果显示，关于痤疮焕肤的临床试验非常少（N=13）；这些试验大多纳入的患者数量较少，未设对照组且为开放性研究。现有的证据支持在痤疮中使用化学焕肤，因为尽管评估方法、治疗方案和患者人群存在差异，但所有试验的结果总体上均较为有利。值得注意的是，尚无化学焕肤治疗痤疮的研究将痤疮药物作为对照药物。由于并非每份出版物都明确规定是否允许同时使用痤疮药物，因此难以明确评估有多少研究评估了单独焕肤的效果。然而，鉴于除了极少数患者不能耐受其他治疗方法的特殊情况下，很少有临床医生会将浅层化学焕肤作为痤疮的唯一治疗方法，这种做法可能是合理的。
未来，我们需要进一步研究以确定在该适应证中使用化学焕肤的最佳方案。
