Department of Medicine, Immunology Institute, Mount Sinai School of Medicine, One Gustave L. Levy Place, New York, NY 10029, USA.
Immunity. 2010 Oct 29;33(4):479-91. doi: 10.1016/j.immuni.2010.09.013.
There are great interest and demand for the development of vaccines to prevent and treat diverse microbial infections. Mucosal vaccines elicit immune protection by stimulating the production of antibodies at mucosal surfaces and systemic districts. Being positioned in close proximity to a large community of commensal microbes, the mucosal immune system deploys a heterogeneous population of cells and a complex regulatory network to maintain the balance between surveillance and tolerance. A successful mucosal vaccine relies on leveraging the functions of these immune cells and regulatory components. We review the important cellular interactions and molecular pathways underlying the induction and regulation of mucosal antibody responses and discuss their implications on mucosal vaccination.
人们对于开发预防和治疗各种微生物感染的疫苗有着浓厚的兴趣和需求。黏膜疫苗通过刺激黏膜表面和全身区域产生抗体来引发免疫保护。由于位于与大量共生微生物密切相关的位置，黏膜免疫系统利用多种细胞群和复杂的调控网络来维持监视和耐受之间的平衡。成功的黏膜疫苗依赖于利用这些免疫细胞和调控成分的功能。我们综述了诱导和调节黏膜抗体应答的重要细胞相互作用和分子途径，并讨论了它们对黏膜免疫接种的影响。
