Department of Dermatology, University of Iowa, Iowa City, Iowa, USA.
J Dermatolog Treat. 2012 Apr;23(2):83-9. doi: 10.3109/09546634.2010.507704. Epub 2010 Oct 31.
Topical 5-fluorouracil has proved to be a useful therapy since its discovery nearly 50 years ago for the treatment of a range of cancers (e.g. skin, colorectal, breast) and dermatological conditions (e.g. cancerous and precancerous conditions such as actinic keratosis, benign tumors, nail psoriasis, mycosis fungoides, and porokeratoses). As a result of the enduring utility in these conditions, the mechanism of action of 5-fluorouracil has been studied extensively in vivo and in vitro. This review provides an overview of the history and general mechanism of action of 5-fluorouracil and discusses the dermatological implications of the drug, including systemic absorption, selectivity for abnormal skin, targeted delivery, and skin-specific molecular effects. Considerations of 5-fluorouracil treatment in specific dermatological settings are also discussed, as well as recent findings of a role for 5-fluorouracil in the treatment of photoaging.
局部用 5- 氟尿嘧啶自近 50 年前发现以来，已被证明是一种有效的治疗方法，可用于治疗多种癌症（例如皮肤、结直肠、乳腺）和皮肤病（例如光化性角化病、良性肿瘤、甲银屑病、蕈样肉芽肿和角化棘皮瘤等癌前和癌前状态）。由于在这些疾病中具有持久的效用，因此已在体内和体外对 5- 氟尿嘧啶的作用机制进行了广泛研究。本文综述了 5- 氟尿嘧啶的历史和一般作用机制，并讨论了该药物在皮肤病学方面的意义，包括全身吸收、对异常皮肤的选择性、靶向递药和皮肤特异性分子作用。本文还讨论了 5- 氟尿嘧啶在特定皮肤病学环境中的治疗考虑因素，以及 5- 氟尿嘧啶在治疗光老化方面的新发现。
