β3 肾上腺素能受体基因 Trp64Arg 突变与代谢综合征的关系：一项为期七年的随访研究。

Relationship between Trp64Arg mutation in the β3-adrenergic receptor gene and metabolic syndrome: a seven-year follow-up study.

机构信息

Department of Endocrinology, Bethune International Peace Hospital, Shijiazhuang, Hebei 050082, China.

出版信息

Chin Med J (Engl). 2010 Sep;123(17):2375-8.

Abstract

BACKGROUND

It has been shown that the β3-adrenergic receptor (β3-AR) gene Trp64Arg mutation was closely related to obesity and insulin resistance, and may be related to the prevalence of metabolic syndrome (MS). The aim of this study was to investigate the relationship between the β3-AR gene mutation and the prevalence of MS.

METHODS

A seven-year follow-up study was initiated in 2000, with 496 samples of simplex obese subjects (body mass index ≥ 25 kg/m(2)) and 248 normal-weight subjects. According to the β3-AR genotypes, the subjects were classified as Trp64 homozygote group and Arg64 carrier group and after 7 years the prevalence of MS was determined.

RESULTS

According to the baseline profile, there were no significant differences in the adiposity, blood pressure, lipid profile, fasting plasma glucose and fasting insulin between Trp64 homozygote group and Arg64 carrier group either in obesity or normal-weight subjects. The results of follow-up study indicated that in obese men the prevalence rate of MS was much higher in Arg64 carrier group than that in Trp64 homozygote group (54.76% vs. 40.85%, P < 0.05), but there was no statistical difference in women of the above groups. The prevalence rate of MS in obese men of both Trp64 homozygote group and Arg64 carrier obese group were obviously higher than that in women of the above groups (40.85% vs. 18.27% and 54.76% vs 21.28%, all P < 0.005). Differences were not statistically significant in the prevalence of MS for normal weight Trp64 homozygote group and normal weight Arg64 carrier group, either between men, between women, or between men and women. Comparison of populations indicated that no matter with the β3-AR gene mutation or not, the prevalence of MS in obese subjects was significantly higher than normal weight subjects (χ(2) = 28.240 and χ(2) = 15.586, all P < 0.005). Logistic analysis showed that the mutation of β3-AR gene was associated with the prevalence of MS in men.

CONCLUSION

The mutation of β3-AR gene is the independent risk factor for the prevalence of MS in men.

摘要

背景

β3-肾上腺素能受体（β3-AR）基因 Trp64Arg 突变与肥胖和胰岛素抵抗密切相关，可能与代谢综合征（MS）的流行有关。本研究旨在探讨β3-AR 基因突变与 MS 患病率的关系。

方法

2000 年开始进行为期 7 年的随访研究，纳入 496 例单纯性肥胖受试者（体重指数≥25kg/m2）和 248 例正常体重受试者。根据β3-AR 基因型，将受试者分为 Trp64 纯合子组和 Arg64 携带者组，7 年后确定 MS 的患病率。

结果

根据基线特征，肥胖和正常体重受试者中，Trp64 纯合子组和 Arg64 携带者组之间的体脂、血压、血脂、空腹血糖和空腹胰岛素均无显著差异。随访研究结果表明，在肥胖男性中，Arg64 携带者组 MS 的患病率明显高于 Trp64 纯合子组（54.76%比 40.85%，P<0.05），但两组女性之间无统计学差异。肥胖男性 Trp64 纯合子组和 Arg64 携带者组 MS 的患病率均明显高于女性（40.85%比 18.27%和 54.76%比 21.28%，均 P<0.005）。无论是否存在β3-AR 基因突变，正常体重 Trp64 纯合子组和 Arg64 携带者组的 MS 患病率在男性、女性或男女之间均无统计学差异。人群比较表明，无论是否存在β3-AR 基因突变，肥胖者的 MS 患病率均明显高于正常体重者（χ2=28.240 和 χ2=15.586，均 P<0.005）。Logistic 分析显示，β3-AR 基因突变与男性 MS 的患病率有关。