Faculty of Management, Shizuoka Sangyo University, Shizuoka, Japan.
Acta Paediatr. 2013 Jun;102(6):613-9. doi: 10.1111/apa.12149. Epub 2013 Jan 22.
To investigate the association between Trp64Arg polymorphism of the beta3-adrenergic receptor (ADRB3) gene and total fat mass, abdominal fat distribution, other metabolic derangements and metabolic syndrome (MS) in Japanese children.
Molecular screening of the ADRB3 gene polymorphism (Trp64Trp, Trp64Arg and Arg64Arg) was carried out in 132 children aged 6-12 years: 73 were obese (45 boys) and 59 were not obese (27 boys). Visceral fat (VF) and subcutaneous fat (SF) area were measured using magnetic resonance imaging, blood pressure, lipid and glucose profiles.
The frequencies of Arg carriers (Trp64Arg or Arg64Arg) were significantly higher in obese children with MS, compared to obese children without MS and nonobese children. In obese children, Arg carriers had significantly higher VF area, systolic and diastolic blood pressure, and low-density lipoprotein cholesterol and triglyceride than Arg noncarriers (Trp64Trp). However, there were no differences in total fat mass and SF area between the two groups. In nonobese children, none of these parameters differed significantly between Arg carriers and noncarriers.
Trp64Arg polymorphism of the ADRB3 gene may affect VF accumulation and be associated with MS, a cluster of conditions involving aggravated lipid metabolism and higher blood pressure, in Japanese children.
探讨β3-肾上腺素能受体（ADRB3）基因 Trp64Arg 多态性与日本儿童总脂肪量、腹部脂肪分布、其他代谢异常及代谢综合征（MS）的关系。
对 132 名 6-12 岁儿童进行 ADRB3 基因多态性（Trp64Trp、Trp64Arg 和 Arg64Arg）的分子筛查：73 名肥胖（45 名男孩），59 名不肥胖（27 名男孩）。采用磁共振成像测量内脏脂肪（VF）和皮下脂肪（SF）面积，检测血压、血脂和血糖谱。
肥胖伴 MS 儿童的 Arg 携带者（Trp64Arg 或 Arg64Arg）频率明显高于肥胖不伴 MS 儿童和非肥胖儿童。在肥胖儿童中，Arg 携带者的 VF 面积、收缩压和舒张压、低密度脂蛋白胆固醇和甘油三酯明显高于 Arg 非携带者（Trp64Trp）。然而，两组间总脂肪量和 SF 面积无差异。在非肥胖儿童中，Arg 携带者和非携带者之间的这些参数没有明显差异。
ADRB3 基因 Trp64Arg 多态性可能影响 VF 蓄积，并与日本儿童中涉及脂质代谢加重和血压升高的一系列代谢异常及 MS 相关。
