Department of Chemical Engineering, University of Texas at Austin, Austin, TX 78712, USA.
Int J Pharm. 2011 Oct 10;418(1):13-7. doi: 10.1016/j.ijpharm.2010.10.037. Epub 2010 Oct 27.
The Higuchi model for the rate of drug release from matrix devices where the drug loading exceeds the solubility in the matrix medium, whose 50-year anniversary is celebrated in this issue, has proven to be a robust framework and an invaluable tool in developing a significant part of the modern controlled drug delivery industry. This paper reviews the conceptual and mathematical bases for this model and some consequences of its inherent assumptions. In addition, selected extensions of the model that have proven useful over the years are summarized. These include the effects of external mass transfer resistance and spatial variations of drug loading.
Higuchi 模型是用于描述药物释放的模型，适用于药物负载超过基质介质中溶解度的情况。在本期中，我们庆祝了 Higuchi 模型诞生 50 周年，该模型已被证明是开发现代控制药物释放行业的重要部分的稳健框架和宝贵工具。本文回顾了该模型的概念和数学基础，以及其固有假设的一些结果。此外，还总结了该模型多年来证明有用的一些扩展，包括外部传质阻力和药物负载空间变化的影响。
