Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland.
Vet J. 2011 Oct;190(1):55-9. doi: 10.1016/j.tvjl.2010.09.017. Epub 2010 Oct 28.
The efficacy of ketoprofen in the treatment of non-infectious lameness in sows was examined in a double-blinded study. Two dose rates of oral ketoprofen were compared to placebo treatment over five consecutive days. Lameness was assessed with a five-grade scoring system prior to and on the last day of the treatment. The rate of treatment success was 54.3% for the ketoprofen 4mg/kg group (n=46), 53.2% for the ketoprofen 2mg/kg group (n=47) and 20.8% for the pigs in the placebo group (n=48). The difference between both ketoprofen groups and the placebo group was significant (P=0.001), but there was no difference between the two ketoprofen groups (P=0.78). Oral ketoprofen was well tolerated and no adverse events were observed. As lameness is a very common problem in sows, oral ketoprofen appeared to be a practical way to alleviate pain and improve the welfare of sows.
在一项双盲研究中,考察了酮洛芬治疗母猪非传染性跛行的疗效。将两种口服酮洛芬剂量与安慰剂治疗进行了为期 5 天的比较。跛行在治疗前和治疗的最后一天用五级评分系统进行评估。酮洛芬 4mg/kg 组(n=46)的治疗成功率为 54.3%,酮洛芬 2mg/kg 组(n=47)为 53.2%,安慰剂组(n=48)为 20.8%。酮洛芬两组与安慰剂组之间的差异具有统计学意义(P=0.001),但两组之间没有差异(P=0.78)。口服酮洛芬耐受性良好,未观察到不良反应。由于跛行是母猪中非常常见的问题,因此口服酮洛芬似乎是一种减轻疼痛和提高母猪福利的实用方法。