Department of Chemistry, University of Massachusetts, 710 North Pleasant Street, Amherst, MA 01003, USA.
Curr Opin Chem Biol. 2010 Dec;14(6):828-34. doi: 10.1016/j.cbpa.2010.10.001. Epub 2010 Oct 27.
Covalent and non-covalent conjugation of proteins to nanoparticles provides access to functional hybrid systems with applications in biotechnology, medicine, and catalysis. The creation of effective conjugates requires the retention of protein structure and function, a challenging task. In this review we discuss successes, challenges and opportunities in the area of protein-nanoparticle bioconjugation.
蛋白质与纳米粒子的共价和非共价偶联为生物技术、医学和催化等领域的应用提供了功能性杂化系统。创建有效的缀合物需要保留蛋白质的结构和功能，这是一项具有挑战性的任务。在这篇综述中，我们讨论了蛋白质-纳米粒子生物缀合领域的成功、挑战和机遇。
