Karlsruhe Institute of Technology (KIT), Institute for Biological Interfaces (IBG 1), Hermann-von-Helmholtz-Platz 1, D-76344, Eggenstein-Leopoldshafen, Germany.
Adv Mater. 2019 Jun;31(26):e1806294. doi: 10.1002/adma.201806294. Epub 2019 Feb 15.
In the past 35 years, DNA nanotechnology has grown to a highly innovative and vibrant field of research at the interface of chemistry, materials science, biotechnology, and nanotechnology. Herein, a short summary of the state of research in various subdisciplines of DNA nanotechnology, ranging from pure "structural DNA nanotechnology" over protein-DNA assemblies, nanoparticle-based DNA materials, and DNA polymers to DNA surface technology is given. The survey shows that these subdisciplines are growing ever closer together and suggests that this integration is essential in order to initiate the next phase of development. With the increasing implementation of machine-based approaches in microfluidics, robotics, and data-driven science, DNA-material systems will emerge that could be suitable for applications in sensor technology, photonics, as interfaces between technical systems and living organisms, or for biomimetic fabrication processes.
在过去的 35 年里，DNA 纳米技术已经发展成为化学、材料科学、生物技术和纳米技术交叉领域中一个极具创新性和活力的研究领域。本文简要总结了 DNA 纳米技术各个分支学科的研究现状，涵盖了从纯粹的“结构 DNA 纳米技术”到蛋白质-DNA 组装、基于纳米粒子的 DNA 材料和 DNA 聚合物，再到 DNA 表面技术。该综述表明，这些分支学科正在越来越紧密地融合在一起，并表明这种整合对于开启下一阶段的发展至关重要。随着基于机器的方法在微流控、机器人技术和数据驱动科学中的应用日益增多，将出现适合于传感器技术、光子学、技术系统与生物体之间的接口以及仿生制造过程等应用的 DNA 材料系统。
