Psychiatry Department, University of Michigan, Ann Arbor, MI, USA.
Infant Behav Dev. 2011 Feb;34(1):26-34. doi: 10.1016/j.infbeh.2010.07.002. Epub 2010 Oct 29.
To explore the interplay of maternal depressive symptoms on the infant limbic-hypothalamic-pituitary axis (LHPA) and neurological development.
Pregnant women were monitored for depressive symptoms using the Beck Depression Inventory (BDI) at 28, 32, and 37 weeks of gestation and at delivery. A mixture growth curve analysis divided the women into three risk groups: low/stable, intermediate, and high/increasing depression based on BDI scores. The infant neuroendocrine system was examined using cord blood for adrenocorticotrophic hormone (ACTH) and cortisol measurements. Two-week-old infants were examined using Neonatal Intensive Care Unit Neurobehavioral Scale (NNNS).
Infants born to women of the high/increasing depression group had significant ACTH elevation at birth. On NNNS examination, these infants were more hypotonic and habituated to auditory and visual stimuli.
When compared to non-depressed women, maternal depressive symptoms, even in the absence of major depressive disorder, appeared to facilitate a different developmental pathway for the infant LHPA and early neurological development.
探讨产妇抑郁症状对婴儿边缘-下丘脑-垂体轴（LHPA）和神经发育的相互作用。
在妊娠 28、32 和 37 周及分娩时，使用贝克抑郁量表（BDI）监测孕妇的抑郁症状。基于 BDI 评分，混合增长曲线分析将孕妇分为低/稳定、中、高/增加抑郁三个风险组。通过脐带血检测促肾上腺皮质激素（ACTH）和皮质醇水平，评估婴儿的神经内分泌系统。对出生后两周的婴儿进行新生儿重症监护病房神经行为量表（NNNS）检查。
出生于高/增加抑郁组的母亲的婴儿在出生时 ACTH 显著升高。在 NNNS 检查中，这些婴儿的张力较低，对听觉和视觉刺激的习惯化程度较低。
与非抑郁的女性相比，即使没有重度抑郁症，产妇的抑郁症状似乎也会为婴儿的 LHPA 和早期神经发育开辟一条不同的发育途径。
