Case Western Reserve University School of Medicine, Cleveland, OH, USA.
Am J Otolaryngol. 2011 Nov-Dec;32(6):557-63. doi: 10.1016/j.amjoto.2010.09.010. Epub 2010 Oct 29.
Papillary squamous cell carcinoma (PSCC) is a rare malignancy that has been associated with human papillomavirus. We present all cases of this disease at a single academic teaching hospital over the last 30 years.
A retrospective chart review was performed for all patients with a diagnosis of PSCC. Of 65 patients identified, 52 were included after meeting established diagnostic criteria. Chart reviews were performed for patient demographics, overall survival, and disease-free survival.
Mean age at diagnosis was 65 years, with a male to female ratio of 2.3:1. The majority of lesions (n = 34, 65.4%) arose in areas commonly affected by benign squamous papillomas, with the laryngopharynx the most commonly affected (n = 19, 36.5%), followed by the oral cavity (n = 18, 34.6%), sinonasal tract (n = 8, 15.4%), and oropharynx (n = 7, 13.5%). Two- and 5-year disease-free survival rate was 68% and 46%, respectively. Overall survival rate was 90% and 72% at 2 and 5 years, respectively.
Papillary squamous cell carcinoma of the head and neck is a distinct variant of conventional squamous cell carcinoma with a good prognosis despite high locoregional recurrence rates. Histology and subsite localization corroborate existing evidence that human papillomavirus may be involved.
乳头状鳞状细胞癌（PSCC）是一种罕见的恶性肿瘤，与人类乳头瘤病毒有关。我们报告了过去 30 年来在一家学术教学医院的所有此类疾病病例。
对所有诊断为 PSCC 的患者进行了回顾性病历审查。在确定了 65 名患者中，符合既定诊断标准的 52 名患者被纳入研究。对患者的人口统计学数据、总生存率和无病生存率进行了病历审查。
诊断时的平均年龄为 65 岁，男女比例为 2.3:1。大多数病变（n=34，65.4%）发生在良性鳞状乳头状瘤常见的部位，其中喉咽部最常见（n=19，36.5%），其次是口腔（n=18，34.6%）、鼻-鼻窦（n=8，15.4%）和口咽（n=7，13.5%）。2 年和 5 年无病生存率分别为 68%和 46%。总生存率分别为 90%和 72%，在 2 年和 5 年时。
头颈部乳头状鳞状细胞癌是一种独特的常规鳞状细胞癌变体，尽管局部区域复发率较高，但预后良好。组织学和亚部位定位证实了现有的证据，即人类乳头瘤病毒可能参与其中。
