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微创与传统双瓣手术的比较:倾向匹配比较。

Less invasive versus conventional double-valve surgery: a propensity-matched comparison.

机构信息

Center for Aortic Surgery and the Marfan and Connective Tissue Disorder Clinic, Heart and Vascular Institute, Department of Thoracic and Cardiovascular Surgery, Cleveland Clinic, Cleveland, Ohio, USA.

出版信息

J Thorac Cardiovasc Surg. 2011 Jun;141(6):1461-8.e4. doi: 10.1016/j.jtcvs.2010.05.053. Epub 2010 Oct 30.

Abstract

OBJECTIVE

Less invasive approaches to double-valve surgery are used for improved cosmesis; however, few studies have investigated their effect on outcome. We sought to compare these less invasive approaches with conventional full sternotomy.

METHODS

From January 1995 to January 2004, 114 patients underwent primary double-valve surgery through a less invasive approach and 381 through conventional sternotomy. Because there were important differences in the patients' characteristics, a propensity score based on 42 factors was used to obtain 81 well-matched patient pairs (71% of possible matches) for comparison of in-hospital morbidity and mortality, mediastinal drainage, transfusion requirements, pulmonary function, pain, and long-term survival.

RESULTS

In-hospital mortality was similar for propensity-matched patients: 6.2% (5/81) for those undergoing less invasive surgery and 2.5% (2/81) for those undergoing conventional sternotomy (P > .4). Occurrences of stroke (P > .9), renal failure (P = .4), myocardial infarction (P > .9), and infection (P > .9) were also similar. However, 24-hour mediastinal drainage was less after less invasive surgery (median, 250 vs 400 mL; P < .0001), but a similar proportion of patients received transfusions (28% vs 40%, P = .2). An equivalent proportion of patients were extubated in the operating room (7.7% vs 7.0%, P > .9), and median hours to extubation were similar (5.0 vs 6.5 hours). Pain scores were equivalent (P > .3). Long-term survival was also similar (82% and 76% at 10 years, P = .07).

CONCLUSIONS

Within that portion of the spectrum of double-valve surgery in which propensity matching was possible, less invasive surgery had cosmetic and blood product use advantages over conventional surgery and no apparent detriments.

摘要

目的

采用微创方法进行双瓣膜手术,以改善美容效果;然而,很少有研究调查其对结果的影响。我们旨在比较这些微创方法与传统的胸骨正中切开术。

方法

1995 年 1 月至 2004 年 1 月,114 例患者通过微创途径和 381 例患者通过传统胸骨切开术接受了原发性双瓣膜手术。由于患者的特征存在重要差异,因此使用基于 42 个因素的倾向评分来获得 81 对匹配良好的患者对(可能匹配的 71%),以比较住院期间的发病率和死亡率、纵隔引流、输血需求、肺功能、疼痛和长期生存。

结果

在倾向评分匹配的患者中,院内死亡率相似:微创组为 6.2%(5/81),传统胸骨切开组为 2.5%(2/81)(P>.4)。发生中风(P>.9)、肾衰竭(P =.4)、心肌梗死(P>.9)和感染(P>.9)的情况也相似。然而,微创手术后 24 小时纵隔引流较少(中位数 250 比 400 毫升;P <.0001),但接受输血的患者比例相似(28%比 40%,P =.2)。同样比例的患者在手术室拔管(7.7%比 7.0%,P>.9),拔管中位时间相似(5.0 比 6.5 小时)。疼痛评分也相似(P>.3)。长期生存率也相似(10 年时分别为 82%和 76%,P =.07)。

结论

在可以进行倾向匹配的双瓣膜手术范围内,微创术具有美容和血液制品使用方面的优势,而没有明显的不利影响。

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