Yambe T, Nitta S, Katahira Y, Sonobe T, Tanaka M, Miura M, Satoh N, Mohri H, Yoshizawa M, Takeda H
Department of Medical Engineering and Cardiology, Tohoku University, Sendai, Japan.
Int J Artif Organs. 1990 Oct;13(10):681-6.
To determine the effect of left ventricular assist device (LVAD) pumping on sympathetic tone, renal sympathetic nerve activity (RSNA) was detected in acute animal experiments. Our TH-7B pneumatically driven, sac-type ventricular assist device was used in 7 adult mongrel dogs. RSNA was detected by the use of bipolar electrodes attached to the left renal sympathetic nerve. RSNA was amplified and integrated by use of an R-C integrator circuit. The area of the integrated nerve discharge per unit time was calculated in the computer system and expressed as RSNA per unit time. During LVAD pumping, RSNA decreased with increase in blood pressure, with an increase in pulmonary artery flow, and with a decrease in left atrial pressure. These data suggest that LVAD has an effect on the sympathetic nervous system which is mediated by the aortic and cardiopulmonary baroreflex system.
为了确定左心室辅助装置（LVAD）泵血对交感神经张力的影响，在急性动物实验中检测了肾交感神经活动（RSNA）。我们使用TH - 7B气动驱动的囊式心室辅助装置对7只成年杂种犬进行实验。通过将双极电极附着于左肾交感神经来检测RSNA。RSNA通过R - C积分电路进行放大和积分。在计算机系统中计算单位时间内积分神经放电的面积，并表示为单位时间内的RSNA。在LVAD泵血期间，RSNA随着血压升高、肺动脉血流量增加和左心房压力降低而降低。这些数据表明，LVAD对交感神经系统有影响，这种影响是由主动脉和心肺压力反射系统介导的。
