Hematology-Oncology Department, Mashhad University of Medical Science, Mashhad, Iran.
Cancer Epidemiol. 2011 Feb;35(1):26-9. doi: 10.1016/j.canep.2010.09.009. Epub 2010 Oct 30.
Global variations in the frequency of the major sub-types of lymphoma have been reported. However, studies on different sub-types of adult malignant lymphoma had never been conducted in Mashhad, Iran. In this paper, we aimed to identify the major sub-types of malignant lymphoma in our area and compare the distribution with other published studies.
During a retrospective study we evaluate 391 adult patients with lymphoid malignancy from "Omid Hospital" - a cancer research center and an outpatient hematologic clinic in Mashhad - were evaluated from 2000 to 2009. Patients were reclassified using the World Health Organization (WHO) classification.
The frequency of non-Hodgkin lymphomas (NHL) was 92% (n=359) and Hodgkin lymphoma (HL) was 8% (n=32). The most frequent NHL sub-type using WHO classification was diffuse large B cell lymphoma (DLBCL) and the second most common NHL was chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL). The most common sub-type of HL was mixed cellularity. In this study the frequency of primary extranodal NHL in our study was 11.5%, which slightly less common than other eastern countries.
Our findings add to the body of knowledge concerning geographic variations in the descriptive epidemiology of the major lymphoma sub-types. Such observations are extremely important since they potentially point to underling etiological variations.
已经有报道称，全球各地区淋巴瘤的主要亚型的发病率存在差异。然而，在伊朗马什哈德，还从未有过针对成人恶性淋巴瘤的不同亚型进行的研究。本文旨在确定本地区恶性淋巴瘤的主要亚型，并与其他已发表的研究进行比较。
在一项回顾性研究中，我们评估了 2000 年至 2009 年期间来自马什哈德“Omid 医院”（癌症研究中心和门诊血液诊所）的 391 例成人淋巴细胞恶性肿瘤患者。使用世界卫生组织（WHO）分类对患者进行重新分类。
非霍奇金淋巴瘤（NHL）的发病率为 92%（n=359），霍奇金淋巴瘤（HL）的发病率为 8%（n=32）。根据 WHO 分类，最常见的 NHL 亚型是弥漫性大 B 细胞淋巴瘤（DLBCL），其次是慢性淋巴细胞白血病/小淋巴细胞淋巴瘤（CLL/SLL）。HL 最常见的亚型是混合细胞型。在本研究中，我们研究中原发性结外 NHL 的发病率为 11.5%，略低于其他东方国家。
我们的研究结果为主要淋巴瘤亚型描述性流行病学的地域差异提供了更多的知识。这些观察结果非常重要，因为它们可能表明潜在的病因学差异。
