Aledavood Seyed Amir, Ghavam-Nasiri Mohammad Reza, Ghaffarzadegan Kamran, Raziee Hamid Reza, Saboori Golnaz, Anvari Kazem, Mohtashami Samira, Ahadi Mitra, Memar Bahram
Dept. of Radiation oncology, Cancer Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Cancer Prev. 2014 Summer;7(3):147-51.
Various infectious agents like Ebstein Barr Virus (EBV), HTLV-1 and Helicobacter pylori have known as etiologic factors in different sub-types of lymphoma. Although Hepatitis C virus (HCV) has not only been important for its hepatotropism and hepatitis development, but also in recent years its association with some forms of non- Hodgkin's lymphoma (NHL), especially B cell NHL, has reported.In some countries, the rate of B cell NHL development in HCV infected patients was four times more than general population, and then association between HCV infection and B-NHL has proposed in many studies.
To assess this relationship in our geographic region, in a descriptive study; we have evaluated patients with B-NHL in an oncology center in northeast of Iran for HCV infection.
Out of 128 B-NHL patients, HCV Antibody test (with third generation ELISA method) was positive in only one patient, which confirmed with Nested PCR technique. Then the frequency of HCV infection in our patients was 0.7%.
Respecting to the incidence of HCV infection in general population in Iran, which is between 0.5-1%, we couldn't show higher prevalence of HCV infection in NHL patients than general population, and hence couldn't confirm relation between HCV infection and B-NHL in our region.
多种感染因子，如爱泼斯坦-巴尔病毒（EBV）、人类嗜T淋巴细胞病毒1型（HTLV-1）和幽门螺杆菌，已被确认为不同亚型淋巴瘤的病因。丙型肝炎病毒（HCV）不仅因其嗜肝性和肝炎发展而备受关注，近年来其与某些形式的非霍奇金淋巴瘤（NHL），尤其是B细胞NHL的关联也有报道。在一些国家，HCV感染患者中B细胞NHL的发病率是普通人群的四倍，因此许多研究提出了HCV感染与B细胞NHL之间的关联。
为评估我们所在地理区域的这种关系，在一项描述性研究中，我们对伊朗东北部一家肿瘤中心的B细胞NHL患者进行了HCV感染评估。
在128例B细胞NHL患者中，仅1例患者的HCV抗体检测（采用第三代ELISA法）呈阳性，经巢式PCR技术确认。因此，我们的患者中HCV感染率为0.7%。
考虑到伊朗普通人群中HCV感染率在0.5%-1%之间，我们并未发现NHL患者中HCV感染率高于普通人群，因此无法证实我们所在地区HCV感染与B细胞NHL之间的关系。
