Department of Otolaryngology, China Medical University Hospital, Taichung, Taiwan, ROC.
Anticancer Res. 2010 Oct;30(10):4205-8.
To evaluate the association and interaction among hOGG1 genotypic polymorphism, betel quid chewing status and oral cancer risk in Taiwan.
The well-known polymorphic variants of hOGG1, codon 326, were analyzed in association with oral cancer susceptibility, and discussed regarding its joint effect with individual habits on oral cancer susceptibility. In total, 620 patients with oral cancer and 620 healthy controls recruited from the China Medical Hospital were analyzed by polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).
The hOGG1 codon 326 genotypes were differently distributed between the oral cancer and control groups (p=0.0266) and the C allele of hOGG1 codon 326 was significantly (p=0.0046) more frequently found in cancer patients than in controls. We further analyzed the joint effects of gene variants and habits on oral cancer risk and found an interaction between hOGG1 codon 326 genotype and betel quid chewing status. The association of the C allele for hOGG1 codon 326 with oral cancer risk was found to be significant only in the betel quid chewer group (p=0.0149), not in the non-chewer group (p=0.8028).
Our results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with betel quid chewing on the development of oral cancer.
评估 hOGG1 基因多态性、嚼槟榔状态与口腔癌风险之间的关联和相互作用。
分析 hOGG1 密码子 326 这一广为人知的多态性变体与口腔癌易感性的关联，并探讨其与个体习惯对口腔癌易感性的联合作用。总共分析了来自中国医药大学附属医院的 620 名口腔癌患者和 620 名健康对照者的聚合酶链反应和限制性片段长度多态性（PCR-RFLP）。
hOGG1 密码子 326 基因型在口腔癌组和对照组之间的分布不同（p=0.0266），hOGG1 密码子 326 的 C 等位基因在癌症患者中明显比在对照组中更频繁（p=0.0046）。我们进一步分析了基因变异和习惯对口腔癌风险的联合作用，发现 hOGG1 密码子 326 基因型和嚼槟榔状态之间存在交互作用。仅在嚼槟榔组中，hOGG1 密码子 326 的 C 等位基因与口腔癌风险的关联具有统计学意义（p=0.0149），而非嚼槟榔组中无统计学意义（p=0.8028）。
我们的研究结果提供了证据，表明 hOGG1 密码子 326 的 C 等位基因可能与嚼槟榔状态共同作用于口腔癌的发生。
