Wang Yang, Gao Xujie, Wei Feng, Zhang Xinwei, Yu Jinpu, Zhao Hua, Sun Qian, Yan Fan, Yan Cihui, Li Hui, Ren Xiubao
Department of Immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
Tumour Biol. 2015 Feb;36(2):1029-38. doi: 10.1007/s13277-014-2710-6. Epub 2014 Oct 17.
The Ser326Cys polymorphism in the human 8-oxogunaine DNA glycosylase (hOGG1) gene had been implicated in cancer susceptibility. Studies investigating the associations between the Ser326Cys polymorphism and digestion cancer susceptibility showed conflicting results. Therefore, a meta-analysis was performed to derive a more precise estimation of the relationship. We conducted a meta-analysis of 48 studies that included 12,073 cancer cases and 19,557 case-free controls. We assessed the strength of the association using odds ratios (ORs) with 95% confidence intervals (CIs). In our analysis, the hOGG1 Ser326Cys polymorphism was significantly associated with the risk of digestive system cancers (Cys/Cys vs. Ser/Ser: OR = 1.17, 95% CI = 1.00-1.35, P < 0.001; Cys/Cys vs. Cys/Ser + Ser/Ser: OR = 1.14, 95% CI = 1.00-1.29, P < 0.001). In subgroup analyses by cancer types, we found that the hOGG1 Ser326Cys polymorphism may increase hepatocellular cancer and colorectal cancer risks, but decrease the risk of oral cancer. These findings supported that hOGG1 Ser326Cys polymorphism may contribute to the susceptibility of digestive cancers.
人类8-氧代鸟嘌呤DNA糖基化酶（hOGG1）基因中的Ser326Cys多态性与癌症易感性有关。研究调查Ser326Cys多态性与消化系统癌症易感性之间的关联，结果相互矛盾。因此，进行了一项荟萃分析以更精确地估计两者之间的关系。我们对48项研究进行了荟萃分析，这些研究包括12,073例癌症病例和19,557例无癌对照。我们使用比值比（OR）和95%置信区间（CI）评估关联强度。在我们的分析中，hOGG1 Ser326Cys多态性与消化系统癌症风险显著相关（Cys/Cys与Ser/Ser相比：OR = 1.17，95% CI = 1.00 - 1.35，P < 0.001；Cys/Cys与Cys/Ser + Ser/Ser相比：OR = 1.14，95% CI = 1.00 - 1.29，P < 0.001）。在按癌症类型进行的亚组分析中，我们发现hOGG1 Ser326Cys多态性可能增加肝细胞癌和结直肠癌风险，但降低口腔癌风险。这些发现支持hOGG1 Ser326Cys多态性可能与消化系统癌症的易感性有关。
