Department of Pulmonary and Critical Care Medicine, China Medical University Hospital, Taichung, Taiwan, ROC.
Anticancer Res. 2010 Oct;30(10):4141-5.
To evaluate the association and interaction among human 8-oxoguanine DNA glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and lung cancer risk in Taiwan.
The gene for hOGG1 was analyzed via polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 358 patients with lung cancer and 716 healthy controls recruited from the China Medical Hospital.
The hOGG1 codon 326 genotypes were not differently distributed between the lung cancer and control groups (p=0.0809). However, the C allele of hOGG1 codon 326 was significantly (p=0.0198) more frequently found in controls than in cancer patients. We further analyzed the joint effect of genetics and smoking on lung cancer risk and found an interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 C allele-bearing genotypes were significantly associated with lung cancer risk only in the smoker group (p=0.0132), but not in the non-smoker group (p=0.06588).
Our results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with smoking on the development of lung cancer.
评估人 8-氧鸟嘌呤 DNA 糖基化酶 1（hOGG1）基因多态性、吸烟状况与肺癌风险之间的关联和相互作用在台湾。
在中国医药大学附属医院招募的 358 例肺癌患者和 716 例健康对照中，采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）分析 hOGG1 基因。
肺癌组和对照组 hOGG1 密码子 326 基因型分布无差异（p=0.0809）。然而，hOGG1 密码子 326 的 C 等位基因在对照组中显著高于癌症患者（p=0.0198）。我们进一步分析遗传和吸烟对肺癌风险的联合作用，发现 hOGG1 密码子 326 基因型与吸烟状态之间存在交互作用。hOGG1 密码子 326 C 等位基因携带基因型仅在吸烟者中与肺癌风险显著相关（p=0.0132），而非吸烟者中则无相关性（p=0.06588）。
我们的研究结果提供了证据表明，hOGG1 密码子 326 的 C 等位基因可能与吸烟共同作用，增加肺癌的发病风险。
