Graduate Institutes of Basic Medical Science,China Medical University, Taichung, Taiwan, ROC.
Anticancer Res. 2012 Sep;32(9):3799-803.
This study aimed at evaluating the association and interaction among human 8-oxoguanine DNA N-glycosylase 1 (hOGG1) genotypic polymorphism, smoking status and oral cancer risk in Taiwan. For this purpose, the well-known polymorphic variants of hOGG1, codon 326, was analyzed for its association with oral cancer susceptibility, and its joint effect with individual smoking habits on oral cancer susceptibility. In total, 620 patients with oral cancer and 620 healthy controls were recruited from the China Medical Hospital and genotyped. The results showed that the hOGG1 codon 326 genotypes were differently distributed between the oral cancer and control groups (p=0.0266), with the C allele of hOGG1 codon 326 being significantly (p=0.0046) more frequently found in cancer patients than in controls. We further analyzed the genetic-smoking joint effects on oral cancer risk and found an interaction between hOGG1 codon 326 genotypes and smoking status. The hOGG1 codon 326 CC genotype was associated with oral cancer risk only in the smoker group (p=0.0198), but not in the non-chewer group (p=0.8357). Our results provide evidence that the C allele of hOGG1 codon 326 may have a joint effect with smoking on the development of oral cancer.
本研究旨在评估人类 8-氧鸟嘌呤 DNA N-糖基化酶 1（hOGG1）基因多态性、吸烟状况与口腔癌风险之间的关联和相互作用。为此，我们分析了 hOGG1 密码子 326 这一著名的多态性变异，以评估其与口腔癌易感性的关系，及其与个体吸烟习惯对口腔癌易感性的联合作用。总共招募了 620 名口腔癌患者和 620 名健康对照者，他们均来自中国医药大学附属医院，并对其进行了基因分型。结果表明，口腔癌组和对照组的 hOGG1 密码子 326 基因型分布存在差异（p=0.0266），hOGG1 密码子 326 的 C 等位基因在癌症患者中比在对照组中更为常见（p=0.0046）。我们进一步分析了遗传-吸烟联合效应对口腔癌风险的影响，发现 hOGG1 密码子 326 基因型和吸烟状态之间存在相互作用。仅在吸烟者组中，hOGG1 密码子 326 的 CC 基因型与口腔癌风险相关（p=0.0198），而非咀嚼者组中无此相关性（p=0.8357）。我们的研究结果表明，hOGG1 密码子 326 的 C 等位基因可能与吸烟共同作用，增加口腔癌的发病风险。
