Bell G D, Reeve P A, Moshiri M, Morden A, Coady T, Stapleton P J, Logan R F
Br J Clin Pharmacol. 1987 Jun;23(6):703-8. doi: 10.1111/j.1365-2125.1987.tb03104.x.
Intravenous midazolam (mean dose of 6.3 mg) was given to 100 consecutive patients coming to endoscopy. All patients had an ear oximeter attached throughout the procedure to record continuously their levels of oxygen saturation. Eighty-five of the 100 patients had pre-endoscopy respiratory function tests measured, and 82 wore an induction plethysmograph vest to get a continuous qualitative estimate of respiratory rate and excursion throughout the procedure. Following intravenous midazolam a reduction in respiratory excursion was observed in 80% of patients. The initial baseline oxygen saturation of 95.4% fell 3.3% (P less than 0.0005) following intravenous midazolam to 92.1%. During the endoscopic procedure there was a further 3.1% decrease in oxygen saturation to 89.0% (P less than 0.0005) and in 7% the level fell to below 80%. Age, sex, dose of midazolam given and pre-endoscopy respiratory function tests failed to identify those patients at risk of hypoxia during the endoscopy.
对连续100例接受内镜检查的患者静脉注射咪达唑仑（平均剂量6.3毫克）。所有患者在整个检查过程中均佩戴耳部血氧仪，以持续记录其血氧饱和度水平。100例患者中有85例在术前进行了呼吸功能测试，82例患者穿着感应式体积描记法背心，以便在整个检查过程中持续获得呼吸频率和呼吸幅度的定性评估。静脉注射咪达唑仑后，80%的患者呼吸幅度减小。静脉注射咪达唑仑后，初始基线血氧饱和度95.4%下降了3.3%（P<0.0005），降至92.1%。在内镜检查过程中，血氧饱和度进一步下降3.1%，降至89.0%（P<0.0005），7%的患者血氧饱和度降至80%以下。年龄、性别、咪达唑仑给药剂量和术前呼吸功能测试均无法识别那些在内镜检查期间有缺氧风险的患者。
