Rushlow C, Arora K
Department of Biological Sciences, Columbia University, New York, NY 10027.
Semin Cell Biol. 1990 Jun;1(3):137-49.
The establishment of polarity along the dorsal-ventral axis of the Drosophila embryo requires the graded distribution of the dorsal morphogen. Several maternal genes are responsible for the formation of the gradient and their products act in an ordered series of events that begins during oogenesis and involves two different cell types, the oocyte and the follicle cells. The last step in the series results in selective nuclear localization of dorsal proteins, dorsal is thought to regulate the expression of zygotic genes in a concentration dependent way. The zygotic genes determine cell fates in specific regions of the embryo and direct other genes involved in the processes of differentiation.
果蝇胚胎背腹轴极性的建立需要背侧形态发生素的梯度分布。几个母体基因负责形成这种梯度，它们的产物在一系列有序事件中起作用，这些事件始于卵子发生过程，涉及两种不同的细胞类型，即卵母细胞和卵泡细胞。该系列的最后一步导致背侧蛋白的选择性核定位，背侧蛋白被认为以浓度依赖的方式调节合子基因的表达。合子基因决定胚胎特定区域的细胞命运，并指导参与分化过程的其他基因。
