Tee Richard, Lokmic Zerina, Morrison Wayne A, Dilley Rodney J
O'Brien Institute, 42 Fitzroy Street, Fitzroy, Vic. 3065, Australia.
ANZ J Surg. 2010 Oct;80(10):683-93. doi: 10.1111/j.1445-2197.2010.05435.x. Epub 2010 Aug 16.
In heart failure, post-myocardial infarction and some congenital cardiac anomalies, organ transplantation is the only effective cure. Shortage of organ donors and complications of orthotopic heart transplant remain major challenges to the modern field of transplantation. Tissue engineering using cell-based strategies presents itself as a new way of generating functional myocardium. Engineering functional myocardium de novo requires an abundant source of cells that can form cardiomyocytes. These cells may be used with biocompatible scaffold materials to generate a contractile myocardium. Lastly, to sustain the high metabolism of the construct, a functional vasculature needs to be developed with the forming cardiac tissue. This review provides an update on the progress of stem cell research in the context of cardiac tissue development, types of biomaterials used in cardiac tissue engineering (CTE) and currently employed strategies for vascularization in CTE. In addition, a brief overview of strategies utilized in CTE is provided.
在心力衰竭、心肌梗死后以及一些先天性心脏异常中，器官移植是唯一有效的治疗方法。器官供体短缺和原位心脏移植的并发症仍然是现代移植领域的主要挑战。使用基于细胞的策略进行组织工程为生成功能性心肌提供了一种新方法。从头构建功能性心肌需要大量能够形成心肌细胞的细胞来源。这些细胞可与生物相容性支架材料一起使用，以生成可收缩的心肌。最后，为了维持构建体的高代谢，需要与正在形成的心脏组织一起开发功能性脉管系统。本综述提供了关于心脏组织发育背景下干细胞研究进展、心脏组织工程（CTE）中使用的生物材料类型以及CTE中目前采用的血管化策略的最新情况。此外，还简要概述了CTE中使用的策略。
