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磁性 Fe(3)O(4) 纳米颗粒在小鼠体内的药代动力学参数和组织分布。

Pharmacokinetic parameters and tissue distribution of magnetic Fe(3)O(4) nanoparticles in mice.

机构信息

Department of Hematology, Zhongda Hospital, Clinical Medical School, Southeast University, Nanjing, People's Republic of China.

出版信息

Int J Nanomedicine. 2010 Oct 21;5:861-6. doi: 10.2147/IJN.S13662.

DOI:10.2147/IJN.S13662
PMID:21042548
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2963932/
Abstract

BACKGROUND

This study explored the pharmacokinetic parameters and tissue distribution of magnetic iron oxide nanoparticles (Fe(3)O(4) MNPs) in imprinting control region (ICR) mice.

METHODS

The Fe(3)O(4) MNPs were synthesized by chemical coprecipitation, and their morphology and appearance were observed by transmission electron microscopy. ICR mice were divided into a control group and a Fe(3)O(4) MNP-treated group. Probable target organs in ICR mice were observed, and the pharmacokinetic parameters and biodistribution of Fe(3)O(4) MNPs in tissues were identified using atomic absorption spectrophotometry.

RESULTS

Fe(3)O(4) MNPs were spherical with a well distributed particle diameter, and were distributed widely in various target organs and tissues including the heart, liver, spleen, lungs, kidneys, brain, stomach, small intestine, and bone marrow. The majority of Fe(3)O(4) MNPs were distributed to the liver and the spleen. Fe(3)O(4) MNP levels in brain tissue were higher in the Fe(3)O(4) MNP-treated group than in the control group, indicating that Fe(3)O(4) MNPs can penetrate the blood-brain barrier.

CONCLUSION

These results suggest that the distribution of Fe(3)O(4) MNPs was mostly in the liver and spleen, so the curative effect of these compounds could be more pronounced for liver tumors. Furthermore, Fe(3)O(4) MNPs might be used as drug carriers to overcome physiologic barriers.

摘要

背景

本研究探讨了印迹控制区（ICR）小鼠中铁（III）氧（IV）磁纳米粒子（Fe（3）O（4）MNPs）的药代动力学参数和组织分布。

方法

采用化学共沉淀法合成 Fe（3）O（4）MNPs，用透射电子显微镜观察其形态和外观。将 ICR 小鼠分为对照组和 Fe（3）O（4）MNP 处理组。观察 ICR 小鼠可能的靶器官，并用原子吸收分光光度法鉴定 Fe（3）O（4）MNPs 在组织中的药代动力学参数和生物分布。

结果

Fe（3）O（4）MNPs 呈球形，粒径分布均匀，广泛分布于心脏、肝脏、脾脏、肺、肾、脑、胃、小肠和骨髓等各种靶器官和组织中。大多数 Fe（3）O（4）MNPs 分布于肝脏和脾脏。Fe（3）O（4）MNP 处理组脑组织中的 Fe（3）O（4）MNP 水平高于对照组，表明 Fe（3）O（4）MNPs 可以穿透血脑屏障。

结论

这些结果表明，Fe（3）O（4）MNPs 的分布主要在肝脏和脾脏，因此这些化合物对肝脏肿瘤的疗效可能更为明显。此外，Fe（3）O（4）MNPs 可能被用作药物载体以克服生理屏障。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/8be1e20cf325/ijn-5-861f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/adcd81008752/ijn-5-861f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/1a888976183f/ijn-5-861f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/8be1e20cf325/ijn-5-861f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/adcd81008752/ijn-5-861f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/1a888976183f/ijn-5-861f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/caf0/2963932/8be1e20cf325/ijn-5-861f3.jpg

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