Agrawal R P, Sharma R, Garg D, Pokharna R, Kochar D K, Kothari R P
Department of Medicine, SP Medical College, Bikaner 334003.
J Indian Med Assoc. 2010 Mar;108(3):140-3.
A cross-sectional case-control study was conducted in 80 diabetic patients, to evaluate the incidence of gastropathy by endoscopy in type 2 diabetes mellitus. An association between Helicobacter pylori infection and non-gastrointestinal complication of diabetes mellitus was also looked into. Gastric biopsies were subjected to rapid urease test for demonstration of Helicobacter pylori. The fasting blood glucose levels among Helicobacter pylori positive diabetes were 175 +/- 36.5 mg %, and in Helicobacter pylori negative diabetics were 138 +/- 39.4 mg %. The prevalence of endoscopically detectable gastro-intestinal complications were higher in Helicobacter pylori infected diabetics (odd's ratio 4:2; p < 0.05). The total prevalence of Helicobacter pylori positive in diabetics by rapid urease test was statistically significant (p < 0.05). Coronary heart disease was more prevalent in diabetics with Helicobacter pylori infection than those without Helicobacter pylori (57%). The prevalence of H. pylori positivity in other complications such as peripheral vascular diseases, cerebrovascular diseases was not significant. The association between nephropathy, retinopathy and neuropathy with Helicobacter pylori, was also observed and the strong association was seen in diabetic retinopathy (p < 0.001), diabetic neuropathy (p < 0.01) and nephropathy (p < 0.001).
对80例糖尿病患者进行了一项横断面病例对照研究，以评估2型糖尿病患者内镜下胃病的发生率。同时还研究了幽门螺杆菌感染与糖尿病非胃肠道并发症之间的关联。对胃活检组织进行快速尿素酶试验以检测幽门螺杆菌。幽门螺杆菌阳性糖尿病患者的空腹血糖水平为175±36.5mg%，幽门螺杆菌阴性糖尿病患者的空腹血糖水平为138±39.4mg%。幽门螺杆菌感染的糖尿病患者内镜下可检测到的胃肠道并发症患病率更高（比值比4:2；p<0.05）。通过快速尿素酶试验检测，糖尿病患者中幽门螺杆菌阳性的总患病率具有统计学意义（p<0.05）。幽门螺杆菌感染的糖尿病患者冠心病的患病率高于未感染幽门螺杆菌的患者（57%）。在其他并发症如外周血管疾病、脑血管疾病中，幽门螺杆菌阳性的患病率无显著差异。还观察到肾病、视网膜病变和神经病变与幽门螺杆菌之间的关联，并且在糖尿病视网膜病变（p<0.001）、糖尿病神经病变（p<0.01）和肾病（p<0.001）中发现了强关联。
