Department of Geriatric Medicine, Ziaeian Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Iran University of Medical Sciences, Tehran, Iran.
Mol Genet Genomic Med. 2020 Apr;8(4):e1157. doi: 10.1002/mgg3.1157. Epub 2020 Feb 17.
Helicobacter pylori is one of the most prevalent infection worldwide. It affects individuals of different age groups. Elderly people tend to resist eradication treatment and worsening of infection can lead to several gastric and non-gastric pathologies. Aging-associated cellular and molecular alteration can increase the risk of other pathologies such as osteoporosis, Alzheimer's disease, Parkinson's disease, respiratory and renal dysfunction, and cancer in geriatric patients, more than other age groups. This review article highlights some of the most common old age diseases and the role of H. pylori infection as a risk factor to worsen the conditions, presented by the molecular evidences of these associations. These studies can help clinicians to understand the underlying pathogenesis of the disease and identify high-risk patients, aiding clearer diagnosis and treatment.
幽门螺杆菌是全球最普遍的感染之一。它影响不同年龄组的个体。老年人往往难以抵抗根除治疗，感染恶化可导致多种胃部和非胃部疾病。与年龄相关的细胞和分子改变会增加老年患者发生其他疾病的风险，如骨质疏松症、阿尔茨海默病、帕金森病、呼吸和肾功能障碍以及癌症，比其他年龄组更高。这篇综述文章强调了一些最常见的老年疾病以及幽门螺杆菌感染作为加重病情的危险因素的作用，这些关联的分子证据也有所呈现。这些研究可以帮助临床医生了解疾病的潜在发病机制，并识别高危患者，从而更明确地诊断和治疗。
