Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
J Nat Prod. 2010 Nov 29;73(11):1751-5. doi: 10.1021/np1001779. Epub 2010 Nov 2.
Seven new prenylated acylphloroglucinols, yungensins A-G, were isolated from the diethyl ether extract of the scaly rhizomes and roots of an Argentine collection of the fern Elaphoglossum yungense. All the compounds contained a geranyl group attached to the filicinic acid-type residue. The diethyl ether extract and yungensins A-F displayed antibacterial effects against Staphylococcus aureus and Pseudomonas aeruginosa with MICs ranging from 10 to 200 μg/mL. All tested acylphloroglucinols, except for yungensin D, caused bacteriolysis of S. aureus at MBC or higher doses (50-200 μg/mL). At 10 μg/mL, the ether extract as well as yungensins A, B, and D-F altered the biofilm production in both microoganisms.
从阿根廷采集的鳞毛蕨属植物大鳞毛蕨的鳞茎和根茎的乙醚提取物中分离得到了 7 个新的肉桂酰基间苯三酚，即 yungensins A-G。所有化合物均含有一个连接在金缕梅酸型残基上的香叶基。乙醚提取物和 yungensins A-F 对金黄色葡萄球菌和铜绿假单胞菌具有抗菌作用，MIC 范围为 10-200 μg/mL。除 yungensin D 外，所有测试的间苯三酚酰基化合物在 MBC 或更高剂量（50-200 μg/mL）下均导致金黄色葡萄球菌的裂解。在 10 μg/mL 时，乙醚提取物以及 yungensins A、B 和 D-F 改变了两种微生物的生物膜产生。
