Department of Neurosurgery, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
Pain Med. 2010 Nov;11(11):1659-65. doi: 10.1111/j.1526-4637.2010.00959.x.
To compare the efficacy of percutaneous vertebroplasty (PV) with conservative therapy for patients with acute vertebral compression fractures.
Prospective, nonrandomized, comparison study.
The efficacy of PV has not been well established because there have been few comparative studies with conservatively treated control groups.
Fifty-five consecutive patients (8 men and 47 women, age 47-94) with osteoporosis and symptomatic acute vertebral compression fractures were enrolled. thirty-two patients received pv, whereas 23 received conservative therapy.
Changes in pain intensity, physical functioning, and pain medication requirement were evaluated.
Both PV and conservative therapy provided pain reduction (P < 0.001), improvements in physical functioning (P < 0.001), and decreased medication (P < 0.001). Reductions in visual analogue pain scores were more significant in the vertebroplasty group at 1 (P < 0.001) and 4 weeks (P < 0.001) but not at 12 months. Improvements in physical functioning were significant at 1 (P < 0.001) and 4 weeks (P < 0.001). Medication requirements were lower in the vertebroplasty group at all three time points.
Pain relief, physical functioning improvement, and medication requirement after vertebroplasty are immediately and significantly better when compared with conservative therapy.
比较经皮椎体成形术（PV）与保守治疗对急性椎体压缩性骨折患者的疗效。
前瞻性、非随机、比较研究。
由于缺乏与保守治疗对照组的比较研究，PV 的疗效尚未得到充分证实。
共纳入 55 例连续就诊的骨质疏松症伴症状性急性椎体压缩性骨折患者（8 名男性，47 名女性，年龄 47-94 岁）。32 例患者接受了 PV 治疗，23 例患者接受了保守治疗。
评估疼痛强度、躯体功能和止痛药物需求的变化。
PV 和保守治疗均能减轻疼痛（P < 0.001）、改善躯体功能（P < 0.001）和减少药物用量（P < 0.001）。在 1 周（P < 0.001）和 4 周（P < 0.001）时，PV 组的视觉模拟评分降低更为显著，但在 12 个月时无显著差异。在 1 周（P < 0.001）和 4 周（P < 0.001）时，躯体功能改善更为显著。在所有三个时间点，PV 组的药物需求均较低。
与保守治疗相比，PV 后疼痛缓解、躯体功能改善和药物需求降低更为显著。
