Breast Biology Group, School of Cancer and Enabling Sciences, Paterson Institute for Cancer Research, University of Manchester;, Manchester, United Kingdom.
Cancer Res. 2010 Nov 15;70(22):8973-6. doi: 10.1158/0008-5472.CAN-10-1559. Epub 2010 Nov 2.
We and others have established that the developmental Notch receptor signaling pathway is active in breast cancer cell lines, as well as in preinvasive and invasive primary samples. Recently, a role for Notch in regulating the hierarchy of stem and progenitor cells in both normal and cancer epithelium has been elucidated. Because inhibiting the Notch receptor signaling pathway is a possible future breast cancer therapy, here, we review the expression and activity of the different ligands and receptors and summarize the various ways in which the pathway's activity can be inhibited, and the likely effects of inhibition on different tumor cell subpopulations.
我们和其他人已经证实，发育中的 Notch 受体信号通路在乳腺癌细胞系以及早期浸润性和浸润性原发性样本中都处于活跃状态。最近， Notch 在调节正常和癌变上皮中的干细胞和祖细胞层次结构中的作用已经被阐明。因为抑制 Notch 受体信号通路是未来一种可能的乳腺癌治疗方法，所以在这里，我们回顾了不同配体和受体的表达和活性，并总结了抑制该通路活性的各种方法，以及抑制对不同肿瘤细胞亚群的可能影响。
