Shahidi M, Zeimer R C, Mori M
Department of Ophthalmology, University of Illinois, Chicago College of Medicine 60612.
Ophthalmology. 1990 Sep;97(9):1120-4. doi: 10.1016/s0161-6420(90)32457-0.
A noninvasive method has been developed that is capable of providing quantitative thickness profiles of the retina. The method was used to map the retinal thickness in five normal human volunteers and determine the reproducibility of the measurements. The reproducibility or equivalent sensitivity of the measurements to detect changes was found to be 5% or 19 microns on the same day and 8% or 31 microns on different days. By averaging the values obtained in five normal subjects, ranging in age from 21 to 43 years (mean, 34 years), a preliminary normal baseline was derived for the thickness profile at the fovea and the thickness cross-section from the optic disc to the fovea. The results of the study indicated that this noninvasive method promises to be of clinical use in diagnosing ocular diseases that produce changes in the thickness of the retinal as well as in monitoring the effectiveness of therapy.
已经开发出一种非侵入性方法，该方法能够提供视网膜的定量厚度剖面图。该方法用于绘制五名正常人类志愿者的视网膜厚度图，并确定测量的可重复性。发现同一天测量的可重复性或检测变化的等效灵敏度为5%或19微米，不同天为8%或31微米。通过对年龄在21至43岁（平均34岁）的五名正常受试者获得的值进行平均，得出了中央凹厚度剖面图以及从视盘到中央凹的厚度横截面的初步正常基线。研究结果表明，这种非侵入性方法有望在诊断引起视网膜厚度变化的眼部疾病以及监测治疗效果方面具有临床应用价值。
