Department of Ophthalmology, Summa Health System, Akron, OH 44304, USA.
Cornea. 2011 Mar;30(3):360-3. doi: 10.1097/ICO.0b013e3181ee67fd.
To report the pathologic changes in the cornea and the lens capsule resulting from copper deposition in a variant of multiple myeloma.
Case report.
Light microscopy of the cornea revealed endothelial cell attenuation with diffuse copper deposition in the central Descemet membrane, which showed thinning, whereas copper banding was seen in the midperipheral and peripheral cornea where the Descemet membrane was normal in thickness. Copper deposition was confirmed by x-ray microanalysis. The anterior lens capsule showed subepithelial copper deposits. Thickening, multilayering, and splitting of the lens capsule were also noted.
We report the pattern of deposition of copper in the Descemet membrane of the cornea and the anterior lens capsule in multiple myeloma, associated with hypercupremia. Descemet membrane thinning and regional differences in copper deposition were noted. Also, thickening and splitting of the lens capsule are a novel observation.
报告多发性骨髓瘤变异型中铜沉积引起的角膜和晶状体囊的病理变化。
病例报告。
角膜的光镜检查显示内皮细胞衰减，中央 Descemet 膜弥漫性铜沉积，膜变薄，而中周边和周边角膜的铜带则显示 Descemet 膜厚度正常。铜沉积通过 X 射线微分析得到证实。前晶状体囊下有铜沉积。还观察到晶状体囊的增厚、多层化和分裂。
我们报告了多发性骨髓瘤中铜在角膜的 Descemet 膜和前晶状体囊中的沉积模式，与高铜血症有关。注意到 Descemet 膜变薄和铜沉积的区域性差异。此外，晶状体囊的增厚和分裂是一个新的观察结果。
