Martin N F, Kincaid M C, Stark W J, Petty B G, Surer J L, Hirst L W, Green W R
Ophthalmology. 1983 Jan;90(1):110-6. doi: 10.1016/s0161-6420(83)34599-1.
Hypercupremia with central deposition of copper in Descemet's membrane and lens capsule has been reported previously in lymphoproliferative disorders in two cases. A 60-year-old white man presented with visual acuity loss and was found to have an iridescent brown corneal and lenticular discoloration. Laboratory investigation revealed hypercupremia secondary to a poorly differentiated adenocarcinoma of the lung. Presence of copper in the eye was confirmed by specific atomic absorption spectra and histochemical stains of ocular tissue. This appears to be the first report of a carcinoma with associated hypercupremia presenting initially with ocular copper deposition.
此前曾有两例报道称，在淋巴增生性疾病中出现高铜血症，铜在Descemet膜和晶状体囊膜中呈中央沉积。一名60岁白人男性因视力丧失就诊，被发现有虹彩褐色角膜和晶状体变色。实验室检查发现高铜血症继发于低分化肺腺癌。通过特定的原子吸收光谱和眼部组织的组织化学染色证实了眼内存在铜。这似乎是首例伴有高铜血症的癌症最初表现为眼部铜沉积的报道。
