Donovan Christopher P, Bhaleeya Swetangi D, Tzekov Radouil T
Ophthalmic Surg Lasers Imaging Retina. 2019 Nov 1;50(11):e324-e326. doi: 10.3928/23258160-20191031-21.
A 46-year-old woman who presented for progressive glare was found to have dense deposition of copper within Descemet's membrane and lens capsule in both eyes (OU). Systemic workup revealed elevated serum copper secondary to multiple myeloma. Following bilateral Descemet stripping automated endothelial keratoplasty and cataract extraction, a green discoloration of the vitreous was noted. The patient was followed for 3 years with serial exams and electroretinograms. Electroretinograms showed declining photopic response amplitude OU, indicative of progressive retinal toxicity from copper. Although retinal toxicity and vitreous copper deposition are common in chalcosis, this appears to be the first case of hypercupremia associated with these findings. [Ophthalmic Surg Lasers Imaging Retina. 2019;50:e324-e326.].
一名46岁因进行性眩光就诊的女性被发现双眼（OU）的Descemet膜和晶状体囊内有致密的铜沉积。全身检查发现继发于多发性骨髓瘤的血清铜升高。在进行双侧Descemet剥脱自动内皮角膜移植术和白内障摘除术后，发现玻璃体呈绿色变色。对该患者进行了3年的连续检查和视网膜电图随访。视网膜电图显示双眼（OU）明视觉反应振幅下降，提示铜所致的进行性视网膜毒性。虽然视网膜毒性和玻璃体铜沉积在铜质沉着症中很常见，但这似乎是首例与这些发现相关的高铜血症病例。[《眼科手术、激光与视网膜成像》。2019；50：e324 - e326。]
