Curr Opin Pulm Med. 2011 Jan;17(1):1-5. doi: 10.1097/MCP.0b013e3283411440.
asthma is a disease that continues to carry a significant health burden on humanity. Vitamin D is thought to play a role in many chronic diseases as it may possess immunomodulatory properties. This article will review the role of vitamin D regulation on the immune system and its potential implication in the pathophysiology of asthma.
vitamin D receptors are present on many cells in the body, specifically peripheral blood mononuclear cells. Vitamin D has been shown to regulate the balance of several pro-inflammatory and anti-inflammatory responses in the immune system. Studies have suggested that prenatal vitamin D intake has an effect on childhood wheezing and asthma. Additionally, vitamin D may play a role in asthma exacerbations, and recent evidence also suggests its importance in steroid resistant asthma.
vitamin D has a complex role on the immune system and its regulation of various aspects of immunity has allowed speculation on its potential role in asthma. However, the net effect of vitamin D on the immune system and its role in asthma still remains unanswered. More research needs to address the diagnostic and therapeutic implications vitamin D may have in the future of asthma management.
哮喘是一种严重危害人类健康的疾病。维生素 D 可能具有免疫调节作用，因此被认为在许多慢性疾病中发挥作用。本文将综述维生素 D 对免疫系统的调节作用及其在哮喘发病机制中的潜在意义。
维生素 D 受体存在于体内许多细胞中，特别是外周血单个核细胞。维生素 D 已被证明可调节免疫系统中几种促炎和抗炎反应的平衡。研究表明，产前维生素 D 摄入对儿童喘息和哮喘有影响。此外，维生素 D 可能在哮喘恶化中起作用，最近的证据还表明其在类固醇耐药性哮喘中的重要性。
维生素 D 对免疫系统具有复杂的作用，其对免疫的各个方面的调节作用使其在哮喘中的潜在作用受到了推测。然而，维生素 D 对免疫系统的净效应及其在哮喘中的作用仍未得到解答。需要更多的研究来探讨维生素 D 在哮喘管理的未来可能具有的诊断和治疗意义。
